Kim Jisun, Kim Jung Jin
Department of Mechanical Engineering, Keimyung University, Daegu 42601, Korea.
Bioengineering (Basel). 2022 Nov 3;9(11):644. doi: 10.3390/bioengineering9110644.
Topology optimization is currently the only way to provide bone microstructure information by enhancing a 600 μm low-resolution image into a 50 μm high-resolution image. Particularly, the recently proposed localized reconstruction method for the region of interest has received much attention because it has a high possibility to overcome inefficiency such as iterative large-scale problems of the conventional reconstruction. Despite the great potential, the localized method should be thoroughly validated for clinical application. This study aims to quantitatively validate the topology optimization-based localized bone microstructure reconstruction method in terms of accuracy and efficiency by comparing the conventional method. For this purpose, this study re-constructed bone microstructure for three regions of interest in the proximal femur by localized and conventional methods, respectively. In the comparison, the dramatically reduced total progress time by at least 88.2% (20.1 h) as well as computational resources by more than 95.9% (54.0 gigabytes) were found. Moreover, very high reconstruction accuracy in the trabecular alignment (up to 99.6%) and morphometric indices (up to 2.71%) was also found. These results indicated that the localized method could reconstruct bone microstructure, much more effectively preserving the originality of the conventional method.
拓扑优化是目前通过将600μm的低分辨率图像增强为50μm的高分辨率图像来提供骨微结构信息的唯一方法。特别是，最近提出的针对感兴趣区域的局部重建方法受到了广泛关注，因为它极有可能克服传统重建方法中诸如迭代大规模问题等低效性。尽管具有巨大潜力，但局部方法在临床应用中仍需进行全面验证。本研究旨在通过与传统方法比较，从准确性和效率方面对基于拓扑优化的局部骨微结构重建方法进行定量验证。为此，本研究分别采用局部方法和传统方法对股骨近端的三个感兴趣区域进行了骨微结构重建。比较发现，总处理时间显著减少了至少88.2%（20.1小时），计算资源减少了超过95.9%（54.0千兆字节）。此外，在小梁排列（高达99.6%）和形态计量指标（高达2.71%）方面也发现了非常高的重建精度。这些结果表明，局部方法能够重建骨微结构，比传统方法更有效地保留其原始特征。
