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棘皮动物化合物的抗炎作用。

Anti-Inflammatory Effects of Compounds from Echinoderms.

机构信息

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai P.O. Box 505055, United Arab Emirates.

出版信息

Mar Drugs. 2022 Nov 3;20(11):693. doi: 10.3390/md20110693.

DOI:10.3390/md20110693
PMID:36355016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9699147/
Abstract

Chronic inflammation can extensively burden a healthcare system. Several synthetic anti-inflammatory drugs are currently available in clinical practice, but each has its own side effect profile. The planet is gifted with vast and diverse oceans, which provide a treasure of bioactive compounds, the chemical structures of which may provide valuable pharmaceutical agents. Marine organisms contain a variety of bioactive compounds, some of which have anti-inflammatory activity and have received considerable attention from the scientific community for the development of anti-inflammatory drugs. This review describes such bioactive compounds, as well as crude extracts (published during 2010-2022) from echinoderms: namely, sea cucumbers, sea urchins, and starfish. Moreover, we also include their chemical structures, evaluation models, and anti-inflammatory activities, including the molecular mechanism(s) of these compounds. This paper also highlights the potential applications of those marine-derived compounds in the pharmaceutical industry to develop leads for the clinical pipeline. In conclusion, this review can serve as a well-documented reference for the research progress on the development of potential anti-inflammatory drugs from echinoderms against various chronic inflammatory conditions.

摘要

慢性炎症会给医疗系统带来沉重负担。目前临床上有几种合成抗炎药，但每种药物都有自己的副作用。地球拥有广阔多样的海洋，海洋中蕴藏着丰富的具有生物活性的化合物，这些化合物的化学结构可能为药物提供有价值的成分。海洋生物含有多种具有抗炎活性的生物活性化合物，这些化合物已引起科学界的广泛关注，并已被用于开发抗炎药物。本综述描述了这些生物活性化合物，以及棘皮动物（海参、海胆和海星）的粗提物（发表于 2010 年至 2022 年期间）。此外，还介绍了它们的化学结构、评估模型和抗炎活性，包括这些化合物的分子机制。本文还强调了这些海洋来源化合物在制药行业的潜在应用，以开发针对各种慢性炎症疾病的临床候选药物。总之，本综述为棘皮动物中具有开发潜力的抗炎药物的研究进展提供了很好的参考，这些药物可用于治疗各种慢性炎症疾病。

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