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绿原酸可缓解MRL/lpr小鼠的狼疮样皮肤损伤和关节炎。

Chlorogenic Acid Relieves the Lupus Erythematosus-like Skin Lesions and Arthritis in MRL/lpr Mice.

作者信息

Wang Ruxuan, Yang Xiaoyi, You Shen, Hao Mengyao, Li Jianguang, Chen Xiaoguang, Jin Jing

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.

出版信息

Pharmaceuticals (Basel). 2022 Oct 27;15(11):1327. doi: 10.3390/ph15111327.

DOI:10.3390/ph15111327
PMID:36355499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9697989/
Abstract

Chlorogenic acid (CGA) is a phenylpropyl substance synthesized through the shikimic acid pathway. In addition to its anti-tumor, anti-inflammatory, and antioxidant abilities, CGA also has immunomodulatory effects. The aim of the present study is to investigate the therapeutic effects of CGA on the skin damage and arthritis caused by systemic lupus erythematosus (SLE) in an MRL/lpr mouse model. In the SLE model, female MRL/lpr mice at the age of 10 weeks old were treated with CGA daily or cyclophosphamide (CTX) weekly via intraperitoneal injection for three months. After treatment, CGA can significantly alleviate the skin and mucous membrane damage caused by SLE and has a certain improvement effect on arthritis. CGA could inhibit dsDNA expression to a certain extent but has no obvious regulation on ANA concentration. The ELISA and BioMAP results indicated that CGA might play an anti-inflammatory role by down-regulating the interleukin (IL)-17 level. In conclusion, our study demonstrates that CGA can alleviate multiorgan damage in MRL/lpr mice by reducing IL-17.

摘要

绿原酸（CGA）是一种通过莽草酸途径合成的苯丙基物质。除了具有抗肿瘤、抗炎和抗氧化能力外，CGA还具有免疫调节作用。本研究的目的是在MRL/lpr小鼠模型中研究CGA对系统性红斑狼疮（SLE）引起的皮肤损伤和关节炎的治疗效果。在SLE模型中，对10周龄的雌性MRL/lpr小鼠每天腹腔注射CGA或每周腹腔注射环磷酰胺（CTX），持续三个月。治疗后，CGA可显著减轻SLE引起的皮肤和黏膜损伤，并对关节炎有一定的改善作用。CGA可在一定程度上抑制双链DNA表达，但对抗核抗体（ANA）浓度无明显调节作用。酶联免疫吸附测定（ELISA）和生物多参数分析平台（BioMAP）结果表明，CGA可能通过下调白细胞介素（IL）-17水平发挥抗炎作用。总之，我们的研究表明，CGA可通过降低IL-17减轻MRL/lpr小鼠的多器官损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/46fdb2595933/pharmaceuticals-15-01327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/ab6984b00612/pharmaceuticals-15-01327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/12a7a56f4020/pharmaceuticals-15-01327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/4fa4e37f518a/pharmaceuticals-15-01327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/ed7f2a0d2a36/pharmaceuticals-15-01327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/718fe4664171/pharmaceuticals-15-01327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/46fdb2595933/pharmaceuticals-15-01327-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/ab6984b00612/pharmaceuticals-15-01327-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/12a7a56f4020/pharmaceuticals-15-01327-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/4fa4e37f518a/pharmaceuticals-15-01327-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/ed7f2a0d2a36/pharmaceuticals-15-01327-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/718fe4664171/pharmaceuticals-15-01327-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8b8/9697989/46fdb2595933/pharmaceuticals-15-01327-g006.jpg

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