Department of Preventative and Rehabilitative Sports and Performance Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
Division of Performance and Health (Sports Medicine), Department of Sport and Sport Science, TU Dortmund University, Dortmund, Germany.
Int J Sports Med. 2023 Apr;44(4):298-308. doi: 10.1055/a-1976-6069. Epub 2022 Nov 10.
The integrative immune markers , and (SII) are established markers in clinical patient care. Adoption of these markers in elite athletics might prove beneficial for monitoring training and health. Blood samples of 195 healthy national Olympic squad athletes were collected before a graded bicycle-ergometric exercise test until complete exhaustion. Measurements included white blood cells, lymphocytes and platelets, allowing for the calculation of the integrative immune markers. Correlations between athlete characteristics (sex, age, sporting discipline, training experience, training volume) and integrative immune marker-values were assessed. In a subgroup analysis a second blood sample was collected from 25 athletes at 1 minute after exercise test to assess its effect on the immune marker levels.An inverse correlation between peak power output and SII-level (Pearson correlation coefficient=-.270, p<.001) and NLR-level (Pearson correlation coefficient=-.249, p<.001) was found. Athletes with higher aerobic fitness had significantly lower values of SII and PLR compared to athletes with lower aerobic fitness. An elevated SII (p=.003) and a reduced PLR (p=.001) was documented as acute response to the exercise test. The integrative immune markers might be a promising tool for monitoring training and health in elite athletes.
整合免疫标志物 和 （SII）是临床患者护理中的既定标志物。在精英运动员中采用这些标志物可能有助于监测训练和健康状况。在一项分级自行车测力计运动测试之前，采集了 195 名健康的国家奥林匹克队运动员的血液样本，直到完全耗尽。测量包括白细胞、淋巴细胞和血小板，从而计算出整合免疫标志物。评估了运动员特征（性别、年龄、运动项目、训练经验、训练量）与整合免疫标志物值之间的相关性。在亚组分析中，从 25 名运动员中采集了第二次血液样本，在运动测试后 1 分钟采集，以评估其对免疫标志物水平的影响。发现峰值功率输出与 SII 水平（皮尔逊相关系数=-.270，p<.001）和 NLR 水平（皮尔逊相关系数=-.249，p<.001）呈负相关。与有氧健身水平较低的运动员相比，有氧健身水平较高的运动员的 SII 和 PLR 值明显较低。运动测试后的急性反应表现为 SII 升高（p=.003）和 PLR 降低（p=.001）。整合免疫标志物可能是监测精英运动员训练和健康状况的有前途的工具。
