Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Department of Emergency Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
BMC Endocr Disord. 2022 Nov 10;22(1):274. doi: 10.1186/s12902-022-01180-7.
A novel non-insulin-based metabolic score for insulin resistance (METS-IR) index has been proposed as a simple and reliable alternative insulin resistance (IR) marker, but its the predictive value in asymptomatic adults with coronary artery calcification (CAC) remains unclear.
We enrolled 1576 participants without cardiovascular disease (CVD), who underwent multidetector computed tomography. Logistic regression, restricted cubic spline models and receiver operating characteristic (ROC) curves were used to examine the association between METS-IR, the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) and triglyceride glucose index (TyG index) and CAC. In multivariate logistic regression analysis, the increase in METS-IR was independently associated with a higher prevalence of CAC (all P < 0.05 in Models 1-3). Furthermore, restricted cubic splines indicated that the significance of METS-IR in predicting CAC was higher than that of other IR indexes. In ROC curve analysis, without considering the P value, the area under the curve of CAC predicted by METS-IR was higher than that of other IR indexes (METS-IR, 0.607; TyG index, 0.603; TG/HDL-C, 0.577).
Compared with other IR indexes, METS-IR may have better discrimination ability in predicting the incidence of CAC in asymptomatic adults without CVD.
一种新的非胰岛素代谢评分（METS-IR）指数被提出作为一种简单可靠的胰岛素抵抗（IR）标志物，但它在无症状冠状动脉钙化（CAC）成人中的预测价值尚不清楚。
我们纳入了 1576 名无心血管疾病（CVD）的参与者，他们接受了多排螺旋 CT 检查。采用逻辑回归、限制性立方样条模型和受试者工作特征（ROC）曲线来研究 METS-IR、甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值和甘油三酯葡萄糖指数（TyG 指数）与 CAC 之间的关系。在多变量逻辑回归分析中，METS-IR 的增加与 CAC 患病率的升高独立相关（模型 1-3 中所有 P 值均<0.05）。此外，限制性立方样条表明，METS-IR 在预测 CAC 方面的意义高于其他 IR 指标。在 ROC 曲线分析中，不考虑 P 值，METS-IR 预测 CAC 的曲线下面积高于其他 IR 指标（METS-IR，0.607；TyG 指数，0.603；TG/HDL-C，0.577）。
与其他 IR 指标相比，METS-IR 可能在预测无 CVD 的无症状成人 CAC 发生率方面具有更好的判别能力。
