Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806, Poznan, Poland.
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569, Poznan, Poland.
J Endocrinol Invest. 2021 Dec;44(12):2831-2843. doi: 10.1007/s40618-021-01608-2. Epub 2021 Jun 16.
Obesity and insulin resistance are considered cardinal to the pathophysiology of metabolic syndrome. Several simple indexes of insulin resistance calculated from biochemical or anthropometric variables have been proposed. The study aimed to assess the diagnostic accuracy of indirect insulin resistance indicators in detecting metabolic syndrome in non-diabetic patients, including TG/HDLc, METS-IR, TyG, TyG-BMI, TyG-WC, TyG-WHtR, and new indicators TyG-NC (TyG-neck circumference) and TyG-NHtR (Tyg-neck circumference to height ratio).
The diagnostic accuracy of eight insulin resistance indexes was assessed using the receiver operating characteristic curves (ROC curves) in 665 adult non-diabetic patients. Then, the analysis was performed after the division into groups with proper body mass index, overweight and obese.
All indexes achieved significant diagnostic accuracy, with the highest AUC (area under the curve) for TyG (0.888) and Tg/HDLc (0.874). The highest diagnostic performance in group with the proper body mass index was shown for TyG (0.909) and TyG-BMI (0.879). The highest accuracy in the group of overweight individuals was presented by TyG (0.884) and TG/HDLc (0.855). TG/HDLc and TyG showed the highest AUC (0.880 and 0.877, respectively) in the group with obesity. Both TyG-NC and TyG-NHtR reached significant areas under the curve, which makes them useful diagnostic tests in metabolic syndrome.
Indirect indices of insulin resistance, including proposed TyG-NC and TyG-NHtR, show an essential diagnostic value in diagnosing metabolic syndrome. TyG and TG/HDLc seem to be the most useful in the Caucasian population.
肥胖和胰岛素抵抗被认为是代谢综合征病理生理学的关键。已经提出了几种从生化或人体测量变量计算得出的简单胰岛素抵抗指数。本研究旨在评估间接胰岛素抵抗指标在检测非糖尿病患者代谢综合征中的诊断准确性，包括 TG/HDLc、METS-IR、TyG、TyG-BMI、TyG-WC、TyG-WHtR 以及新指标 TyG-NC（TyG-颈围）和 TyG-NHtR（TyG-颈围与身高比）。
使用 665 名成年非糖尿病患者的接收者操作特征曲线（ROC 曲线）评估 8 种胰岛素抵抗指数的诊断准确性。然后，在适当体重指数、超重和肥胖的分组中进行分析。
所有指标均具有显著的诊断准确性，其中 TyG（0.888）和 Tg/HDLc（0.874）的 AUC（曲线下面积）最高。在适当体重指数组中，TyG（0.909）和 TyG-BMI（0.879）的诊断性能最高。在超重个体组中，TyG（0.884）和 TG/HDLc（0.855）的准确性最高。在肥胖组中，TG/HDLc 和 TyG 的 AUC（分别为 0.880 和 0.877）最高。TyG-NC 和 TyG-NHtR 均达到显著的曲线下面积，这使它们成为代谢综合征的有用诊断测试。
胰岛素抵抗的间接指标，包括新提出的 TyG-NC 和 TyG-NHtR，在诊断代谢综合征方面具有重要的诊断价值。在白种人群中，TyG 和 TG/HDLc 似乎最有用。
