基于 0D/2D 同结效应对脱氧雪腐镰刀菌烯醇进行电化学发光适体传感器的灵敏且稳定检测及其在食品分析中的应用。
Sensitive and stable detection of deoxynivalenol based on electrochemiluminescence aptasensor enhanced by 0D/2D homojunction effect in food analysis.
机构信息
Key Laboratory of Modern Agriculture Equipment and Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Key Laboratory of Modern Agriculture Equipment and Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China.
出版信息
Food Chem. 2023 Mar 1;403:134397. doi: 10.1016/j.foodchem.2022.134397. Epub 2022 Sep 24.
Sensitive detection for deoxynivalenol (DON) should be developed due to DON as a kind of harmful mycotoxins which can poses health risk to human health even at low concentrations. In this work, an electrochemiluminescence (ECL) DON aptasensor was proposed based on TiC dots/TiC nanosheet (TDTN). Compared with TiC dots and TiC nanosheet, the ECL intensity of TDTN was 4 times of TiC dots and 2 times of TiC nanosheet as emitters. This was attributed to homojunction effect which could provide continuity of band bonding and effectively accelerate charge transfer at the interface. Based on ECL signal changes generated by aptamer and DON fixed on the electrode surface, the ECL aptasensor showed "on-off-on" performances and detected DON specifically in milk, with detection range of 0.001-20 ng/mL and detection limit of 0.3 pg/mL (S/N = 3). Therefore, the constructed ECL aptasensor is a promising detection method for food safety analysis.
由于脱氧雪腐镰刀菌烯醇（DON）是一种有害真菌毒素，即使在低浓度下也会对人体健康构成风险，因此应该开发对 DON 的敏感检测方法。在这项工作中，提出了一种基于 TiC 点/TiC 纳米片（TDTN）的电化学发光（ECL）DON 适体传感器。与 TiC 点和 TiC 纳米片相比，TDTN 的 ECL 强度作为发射器是 TiC 点的 4 倍，是 TiC 纳米片的 2 倍。这归因于同质结效应，该效应可以提供带键的连续性，并在界面处有效加速电荷转移。基于适配体和固定在电极表面上的 DON 产生的 ECL 信号变化，ECL 适体传感器表现出“开-关-开”性能，并特异性地在牛奶中检测 DON，检测范围为 0.001-20ng/mL，检测限为 0.3pg/mL（S/N=3）。因此，构建的 ECL 适体传感器是一种有前途的食品安全分析检测方法。
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