Hyla Kinga, Dusza Izabela, Skaradzińska Aneta
Department of Biotechnology and Food Microbiology, Faculty of Biotechnology and Food Science, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland.
Antibiotics (Basel). 2022 Nov 2;11(11):1536. doi: 10.3390/antibiotics11111536.
Bacteriophage potential in combating bacterial pathogens has been recognized nearly since the moment of discovery of these viruses at the beginning of the 20th century. Interest in phage application, which initially focused on medical treatments, rapidly spread throughout different biotechnological and industrial fields. This includes the food safety sector in which the presence of pathogens poses an explicit threat to consumers. This is also the field in which commercialization of phage-based products shows the greatest progress. Application of bacteriophages has gained special attention particularly in recent years, presumably due to the potential of conventional antibacterial strategies being exhausted. In this review, we present recent findings regarding phage application in fighting major foodborne pathogens, including spp., , spp., and . We also discuss advantages of bacteriophage use and challenges facing phage-based antibacterial strategies, particularly in the context of their widespread application in food safety.
自20世纪初发现这些病毒以来,人们几乎立刻就认识到了噬菌体在对抗细菌病原体方面的潜力。对噬菌体应用的兴趣最初集中在医学治疗上,随后迅速扩展到不同的生物技术和工业领域。这包括食品安全领域,病原体的存在对消费者构成了明确的威胁。这也是基于噬菌体的产品商业化取得最大进展的领域。噬菌体的应用近年来尤其受到特别关注,大概是由于传统抗菌策略的潜力已被耗尽。在本综述中,我们介绍了噬菌体在对抗主要食源性病原体方面的最新研究结果,包括 属、 属、 属、 属和 属。我们还讨论了使用噬菌体的优势以及基于噬菌体的抗菌策略面临的挑战,特别是在其在食品安全领域广泛应用的背景下。