Mondal Haimanti, Thomas John
Centre for Nanobiotechnology, Vellore Institute of Technology (VIT), Vellore 632014, Tamil Nadu, India.
Antibiotics (Basel). 2022 Nov 3;11(11):1546. doi: 10.3390/antibiotics11111546.
Marine habitats are especially complex, with a varied diversity of living organisms. Marine organisms, while living in such intense conditions, have developed great physiological and metabolic potential to survive. This has led them to produce several potent metabolites, which their terrestrial counterparts are unable to produce. Over the past few years, marine have been considered one of the most abundant sources of diverse and novel metabolites. In this work, an attempt was made to isolate from marine sediments in terms of their ability to produce several novel bioactive compounds. A total of 16 different colonies were obtained from marine sediment samples. Among the 16 isolates, 2 isolates demonstrated in vitro antibacterial activity against and However, among them, only one isolate was found to have potent antibacterial activity, and hence, was taken for further analysis. This isolate was designated as VIT01. The bioactive components obtained were extracted and later subjected to Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectroscopy (GC-MS) analyses for identification. Several novel bioactive compounds were reported from the data obtained and were found to have potent antibacterial activity. Hence, they could be used as an alternative to antibiotics for treating several fish pathogens in the aquaculture industry.
海洋栖息地特别复杂，有着多种多样的生物。海洋生物在如此恶劣的条件下生存，已发展出强大的生理和代谢潜能。这使得它们产生了一些陆生生物无法产生的强效代谢物。在过去几年里，海洋生物被认为是多种新颖代谢物最丰富的来源之一。在这项研究中，尝试从海洋沉积物中分离出能够产生几种新型生物活性化合物的生物。从海洋沉积物样本中总共获得了16个不同的菌落。在这16个分离物中，有2个分离物对[具体细菌名称1]和[具体细菌名称2]表现出体外抗菌活性。然而，其中只有一个分离物被发现具有强效抗菌活性，因此被用于进一步分析。这个分离物被命名为VIT01。提取得到的生物活性成分随后进行傅里叶变换红外光谱（FTIR）和气相色谱 - 质谱（GC - MS）分析以进行鉴定。从获得的数据中报告了几种新型生物活性化合物，并且发现它们具有强效抗菌活性。因此，它们可以用作抗生素的替代品，用于治疗水产养殖业中的几种鱼类病原体。
