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微小RNA在唾液腺癌发生和预后中的关键作用

MicroRNAs' Crucial Role in Salivary Gland Cancers' Onset and Prognosis.

作者信息

Bocchetti Marco, Grisolia Piera, Melisi Federica, Ferraro Maria Grazia, De Luca Pietro, Camaioni Angelo, Falco Michela, Abate Marianna, Misso Gabriella, Alfano Roberto, Accardo Nunzio, Oliva Flavia, Cossu Alessia Maria, Caraglia Michele, Scrima Marianna, Ricciardiello Filippo

机构信息

Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Via L. De Crecchio, 7, 80138 Naples, Italy.

Laboratory of Precision and Molecular Oncology, Biogem Scarl, Institute of Genetic Research, Contrada Camporeale, 83031 Ariano Irpino, Italy.

出版信息

Cancers (Basel). 2022 Oct 28;14(21):5304. doi: 10.3390/cancers14215304.

DOI:10.3390/cancers14215304
PMID:36358723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9657964/
Abstract

Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18-25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.

摘要

唾液腺癌（SGC）是一种罕见的异质性疾病，约占所有头颈癌的8.5%。微小RNA（miRNA）由一类高度保守的非编码RNA短单链片段（18 - 25个核苷酸）组成，它们是人类生理和病理状态下关键的基因转录调节因子。然而，它们在唾液腺癌发生和发展中的作用尚不完全清楚。本综述旨在汇编和总结该主题的最新研究结果，重点关注唾液腺癌中主要调节和验证的微小RNA的预后和诊断价值。它们的差异表达可能有助于临床医生进行早期诊断、制定治疗策略和实施精准医学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/3c4a4a4b7b4e/cancers-14-05304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/d88c35d69824/cancers-14-05304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/298015fcd8d7/cancers-14-05304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/3c4a4a4b7b4e/cancers-14-05304-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/d88c35d69824/cancers-14-05304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/298015fcd8d7/cancers-14-05304-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f3a/9657964/3c4a4a4b7b4e/cancers-14-05304-g003.jpg

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Front Oncol. 2022 Feb 9;11:786150. doi: 10.3389/fonc.2021.786150. eCollection 2021.
2
miR-146a Overexpression in Oral Squamous Cell Carcinoma Potentiates Cancer Cell Migration and Invasion Possibly Targeting HTT.口腔鳞状细胞癌中miR-146a的过表达可能通过靶向HTT增强癌细胞的迁移和侵袭。
Front Oncol. 2020 Nov 13;10:585976. doi: 10.3389/fonc.2020.585976. eCollection 2020.
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Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma.
致癌孤儿核受体NR4A3在腺泡细胞癌中与MYB相互作用并协同发挥作用。
Cancers (Basel). 2020 Aug 27;12(9):2433. doi: 10.3390/cancers12092433.
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Prediction of Minor Salivary Gland Carcinoma: A Novel Nomogram and Risk Classification System for Overall Survival and Cancer-Specific Survival.预测小唾液腺癌：一种用于总生存和癌症特异性生存的新的列线图和风险分类系统。
Otolaryngol Head Neck Surg. 2021 Feb;164(2):359-368. doi: 10.1177/0194599820938323. Epub 2020 Jul 21.
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Major and minor salivary gland tumours.大唾液腺和小唾液腺肿瘤。
Crit Rev Oncol Hematol. 2020 Aug;152:102959. doi: 10.1016/j.critrevonc.2020.102959. Epub 2020 May 18.
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Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion.喉癌中淋巴结转移的微小RNA特征定义：miR-449a靶向Notch基因并抑制细胞迁移和侵袭。
Mol Ther Nucleic Acids. 2020 Jun 5;20:711-724. doi: 10.1016/j.omtn.2020.04.006. Epub 2020 Apr 21.
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