Oral Research Center, Qingdao Municipal Hospital, Qingdao, Shandong 266011, P.R. China.
Oncol Rep. 2021 Jan;45(1):58-64. doi: 10.3892/or.2020.7854. Epub 2020 Nov 13.
Oral cancer is one of the leading types of cancer and remains the most common cause of cancer‑related mortality in Asia. The pathogenesis of oral cancer is complicated and, due to lack of accurate diagnostic methods and efficient treatment strategies, oral cancer is responsible for a large number of deaths. Therefore, there is an urgent need for developing novel diagnostic tools and targeted therapies. MicroRNAs (miRNAs) represent a class of small non‑coding RNAs that are key elements and play critical regulatory roles in the pathological processes of various diseases. miRNAs are widely distributed in body fluids and are specifically expressed in different cancers, and they may represent effective biomarkers that may be used for early detection of oral cancer. In addition, miRNAs are involved in oral cancer development, progression and prognosis by targeting a broad range of mRNAs that may be of therapeutic value for oral cancer. The aim of the present review was to summarize the role of miRNAs as new diagnostic tools and potential therapeutic targets in oral cancer, and investigate the underlying molecular mechanisms.
口腔癌是癌症的主要类型之一，仍然是亚洲癌症相关死亡率的最常见原因。口腔癌的发病机制很复杂，由于缺乏准确的诊断方法和有效的治疗策略，口腔癌导致了大量死亡。因此，迫切需要开发新的诊断工具和靶向治疗方法。微小 RNA（miRNA）是一类小的非编码 RNA，是各种疾病病理过程中的关键因素，发挥着关键的调节作用。miRNA 广泛分布于体液中，在不同的癌症中特异性表达，它们可能代表有效的生物标志物，可用于口腔癌的早期检测。此外，miRNA 通过靶向广泛的 mRNA 参与口腔癌的发生、发展和预后，这可能对口腔癌具有治疗价值。本综述的目的是总结 miRNA 作为口腔癌新的诊断工具和潜在治疗靶点的作用，并探讨其潜在的分子机制。
