Șerban Georgiana, Tămaș Flaviu, Bălașa Rodica, Manu Doina, Tămaș Corina, Bălașa Adrian
Doctoral School, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Neurosurgery Clinic, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania.
Diagnostics (Basel). 2022 Oct 30;12(11):2630. doi: 10.3390/diagnostics12112630.
Glioblastoma multiforme (GBM) is the most aggressive brain tumor that occurs in adults. In spite of prompt diagnosis and rapidly administered treatment, the survival expectancy is tremendously poor. Extensive research has been performed in order to establish factors to predict the outcome of GBM patients; however, worldwide accepted prognostic markers are still lacking.
We retrospectively assessed all adult patients who were diagnosed with primary GBM and underwent surgical treatment during a three-year period (January 2017-December 2019) in the Neurosurgery Department of the Emergency Clinical County Hospital of Târgu Mureș, Romania. Our aim was to find any statistically relevant connections between clinical, imagistic, and histopathological characteristics and patients' survival.
A total of 75 patients were eventually included in our statistical analysis: 40 males and 35 females, with a median age of 61 years. The mean tumor dimension was 45.28 ± 15.52 mm, while the mean survival rate was 4 ± 6.75 months. A univariate analysis demonstrated a statistically significant impact of tumor size, pre-, and postoperative KPSI on survival rate. In addition, a Cox multivariate assessment strengthened previous findings regarding postoperative KPSI (regression coefficient -0.03, HR 0.97, 95% CI (HR) 0.96-0.99, = 0.002) as a favorable prognostic factor and GBM size (regression coefficient 0.03, HR 1.03, 95% CI (HR) 1.01-1.05, 0.005) as a poor prognostic marker for patients' survival.
The results of our retrospective study are consistent with prior scientific results that provide evidence supporting the importance of clinical (quantified by KPSI) and imagistic (particularly tumor dimensions) features as reliable prognostic factors in GBM patients' survival.
多形性胶质母细胞瘤（GBM）是成人中最具侵袭性的脑肿瘤。尽管诊断及时且治疗迅速，但预期生存期仍非常短。为了确定预测GBM患者预后的因素，已经进行了广泛的研究；然而，全球公认的预后标志物仍然缺乏。
我们回顾性评估了罗马尼亚特尔古穆列什市急诊临床县医院神经外科在三年期间（2017年1月至2019年12月）诊断为原发性GBM并接受手术治疗的所有成年患者。我们的目的是找出临床、影像学和组织病理学特征与患者生存之间的任何统计学上相关的联系。
共有75例患者最终纳入我们的统计分析：40例男性和35例女性，中位年龄为61岁。肿瘤平均大小为45.28±15.52毫米，而平均生存率为4±6.75个月。单因素分析表明肿瘤大小、术前和术后KPSI对生存率有统计学上的显著影响。此外，Cox多因素评估强化了先前关于术后KPSI（回归系数-0.03，HR 0.97，95%CI（HR）0.96-0.99，P = 0.002）作为有利预后因素以及GBM大小（回归系数0.03，HR 1.03，95%CI（HR）1.01-1.05，P = 0.005）作为患者生存不良预后标志物的研究结果。
我们回顾性研究的结果与先前的科学结果一致，这些结果提供了证据支持临床（由KPSI量化）和影像学（特别是肿瘤大小）特征作为GBM患者生存可靠预后因素的重要性。
