Department of Neurosurgery, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Clinical Research Development Unit of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Cancer Rep (Hoboken). 2024 Nov;7(11):e70050. doi: 10.1002/cnr2.70050.
Glioblastoma multiforme (GBM) poses a significant health challenge as the most common primary malignancy of the adult central nervous system. Gender- and age-related differences in GBM influence prognosis and treatment complexities. This multicenter retrospective study explores gender and age disparities in GBM patients, investigating their impact on occurrence and survival outcomes.
This multicenter retrospective study involved GBM patients treated in Guilan Province, Iran. Patients' data, including age, gender, tumor location, and histopathological diagnosis date, was collected from medical records.
In a cohort of 164 GBM patients, the average age was 54.34 ± 14.16 years, with a higher prevalence among men (59.8%) and patients aged ≤ 60 years (64.6%). The tumor sites exhibited overlapping features in 68% of cases, with the frontal and temporal lobes being the most common specific locations. The mean survival was 12.88 ± 14.14 months, one-year survival of 45%, with women showing significantly higher one-year survival (60% vs. 40%) and longer mean survival (16.14 ± 17.35 vs. 10.75 ± 11.15 months). Furthermore, Patients ≤ 60 years had significantly higher one-year survival (75% vs. 35%). In subgroup analysis, women had significantly higher survival rates in patients ≤ 60 years. However, among patients over 60, women exhibited a more pronounced decline in survival rates, with no statistically significant difference between men and women in this age group.
This study highlights that both age and gender significantly affect GBM survival outcomes. Younger patients, particularly women, exhibited better survival rates, while older patients, especially women, showed poorer outcomes. These findings suggest the need to stratify treatment approaches by both age and gender to optimize care and improve survival in GBM patients. Further research is recommended to explore these associations.
多形性胶质母细胞瘤（GBM）是成人中枢神经系统最常见的原发性恶性肿瘤，对健康构成重大挑战。GBM 患者的性别和年龄相关差异影响预后和治疗的复杂性。这项多中心回顾性研究探讨了 GBM 患者的性别和年龄差异，研究它们对发病和生存结果的影响。
这项多中心回顾性研究纳入了在伊朗吉兰省接受治疗的 GBM 患者。从病历中收集了患者的年龄、性别、肿瘤部位和组织病理学诊断日期等数据。
在 164 名 GBM 患者的队列中，平均年龄为 54.34±14.16 岁，男性（59.8%）和年龄≤60 岁的患者（64.6%）更为常见。肿瘤部位在 68%的病例中具有重叠特征，最常见的特定部位是额叶和颞叶。平均生存时间为 12.88±14.14 个月，一年生存率为 45%，女性的一年生存率显著更高（60%比 40%），平均生存时间更长（16.14±17.35 比 10.75±11.15 个月）。此外，≤60 岁的患者一年生存率显著更高（75%比 35%）。在亚组分析中，≤60 岁的女性患者生存状况显著更好。然而，对于 60 岁以上的患者，女性的生存状况明显恶化，而在这个年龄组中，男女之间的生存状况没有统计学差异。
本研究表明，年龄和性别均显著影响 GBM 的生存结果。年轻患者，尤其是女性，生存状况更好，而老年患者，尤其是女性，生存状况更差。这些发现表明需要根据年龄和性别对治疗方法进行分层，以优化 GBM 患者的护理并提高生存率。建议开展进一步研究以探讨这些关联。
