Experimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, France.
Key-Obs: Preclinical CRO, 45100 Orleans, France.
Cells. 2022 Nov 3;11(21):3483. doi: 10.3390/cells11213483.
The cGAS-STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy.
cGAS-STING 通路在检测微生物和宿主来源的 DNA 后，在先天免疫和适应性免疫的调节中发挥着重要作用。在这里，我们简要总结了 STING 的生物学功能，并回顾了最近的文献，强调了其在呼吸道疾病中的重要贡献。在过去的几年中，人们对 STING 激活的理解取得了巨大的进展，这有利于开发具有潜在治疗益处的 STING 激动剂或拮抗剂。拮抗剂可能减轻 STING 相关的慢性炎症和自身免疫。此外，STING 的药理学激活显示出强大的抗病毒特性，最近在 SARS-CoV-2 感染的情况下得到了证实。当作为佐剂使用时，STING 激动剂也会产生强烈的刺激活性，促进抗肿瘤反应和疫苗的有效性。
