State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Genes (Basel). 2022 Oct 26;13(11):1950. doi: 10.3390/genes13111950.
is an indigenous primary vector of dengue and Zika viruses in China. Understanding the population spatial genetic structure, migration, and gene flow of vector species is critical to effectively preventing and controlling vector-borne diseases. The genetic variation and population structure of populations collected from 22 cities along the Yangtze River Basin were investigated with nine microsatellite loci and the mitochondrial gene. The polymorphic information content (PIC) values ranged from 0.534 to 0.871. The observed number of alleles () values ranged from 5.455 to 11.455, and the effective number of alleles () values ranged from 3.106 to 4.041. The Shannon Index (I) ranged from 1.209 to 1.639. The observed heterozygosity () values ranged from 0.487 to 0.545. The value ranged from 0.047 to 0.212. All populations were adequately allocated to three clades with significant genetic differences. Haplotype 2 is the most primitive molecular type and forms 26 other haplotypes after one or more site mutations. The rapid expansion of high-speed rail, aircraft routes and highways along the Yangtze River Basin have accelerated the dispersal and communication of mosquitoes, which appears to have contributed to inhibited population differentiation and promoted genetic diversity among populations.
是中国登革热和寨卡病毒的本土主要传播媒介。了解媒介物种的种群空间遗传结构、迁移和基因流动对于有效预防和控制媒介传播疾病至关重要。利用 9 个微卫星位点和线粒体基因，对长江流域 22 个城市采集的种群进行了遗传变异和种群结构研究。多态信息含量（PIC）值范围为 0.534 至 0.871。观察到的等位基因数（）值范围为 5.455 至 11.455，有效等位基因数（）值范围为 3.106 至 4.041。香农信息指数（I）范围为 1.209 至 1.639。观察到的杂合度（）值范围为 0.487 至 0.545。值范围为 0.047 至 0.212。所有种群均被充分分配到三个具有显著遗传差异的分支中。单倍型 2 是最原始的分子类型，经过一个或多个位点突变后形成 26 种其他单倍型。长江流域高铁、航线和高速公路的快速发展加速了蚊子的扩散和传播，这似乎抑制了种群分化，促进了种群间的遗传多样性。
