不对称和对称二甲基精氨酸作为儿科肾脏疾病肾功能参数的研究：2003年至2022年文献综述
Asymmetric and Symmetric Dimethylarginines as Renal Function Parameters in Paediatric Kidney Diseases: A Literature Review from 2003 to 2022.
作者信息
Jezierska Michalina, Stefanowicz Joanna
机构信息
Department of Paediatrics, Haematology and Oncology, Faculty of Medicine, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland.
Department of Paediatrics, Haematology and Oncology University Clinical Centre, 7 Debinki Street, 80-952 Gdansk, Poland.
出版信息
Children (Basel). 2022 Oct 31;9(11):1668. doi: 10.3390/children9111668.
Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), inhibitors of nitric oxide synthase, play important roles in many processes in the body. Most data in the literature concern their importance in adult chronic kidney disease (CKD). According to them, SDMA well reflects the glomerular filtration rate (GFR), and higher ADMA concentrations are associated with hypertension and higher mortality. In addition, both substances are recognised cardiovascular risk factors in CKD. The purpose of this review was to summarise the studies on dimethylarginines in renal diseases in children, about which we have much fewer data. The review focuses specifically on dimethylarginine's relation to routinely used renal function parameters. Finally, we analysed 21 of the 55 articles published between 2003 and 2022 on dimethylarginines in kidney diseases in children (from birth to 18 years of age), obtained by searching PubMed/MEDLINE (search terms: "dimethylarginine" and "kidney").
不对称二甲基精氨酸（ADMA）和对称二甲基精氨酸（SDMA）作为一氧化氮合酶的抑制剂，在人体许多生理过程中发挥着重要作用。文献中的大多数数据关注它们在成人慢性肾脏病（CKD）中的重要性。据此，SDMA能很好地反映肾小球滤过率（GFR），而较高的ADMA浓度与高血压及更高的死亡率相关。此外，这两种物质在CKD中均被视为心血管危险因素。本综述的目的是总结关于儿童肾脏疾病中二甲基精氨酸的研究，目前我们在这方面的数据要少得多。该综述特别关注二甲基精氨酸与常用肾功能参数的关系。最后，我们分析了2003年至2022年间发表在PubMed/MEDLINE上的55篇关于儿童（从出生到18岁）肾脏疾病中二甲基精氨酸的文章中的21篇（检索词：“二甲基精氨酸”和“肾脏”）。
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