Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, 15-274 Bialystok, Poland.
Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
Int J Mol Sci. 2022 Nov 2;23(21):13376. doi: 10.3390/ijms232113376.
The incidence of gallstone disease has increased in recent years. The pathogenesis of cholelithiasis is not fully understood. The occurrence of the disease is influenced by both genetic and environmental factors. This article reviews the literature on cholelithiasis in children, with the exception of articles on hematological causes of cholelithiasis and cholelithiasis surgery. The aim of this review is to present the latest research on the pathogenesis of gallstone disease in children. The paper discusses the influence of all factors known so far, such as genetic predisposition, age, infections, medications used, parenteral nutrition, and comorbidities, on the development of gallstone disease. The course of cholelithiasis in the pediatric population is complex, ranging from asymptomatic to life-threatening. Understanding the course of the disease and predisposing factors can result in a faster diagnosis of the disease and administration of appropriate treatment.
近年来，胆石病的发病率有所增加。胆石症的发病机制尚未完全阐明。疾病的发生受遗传和环境因素的共同影响。本文综述了儿童胆石症的文献，除了血液系统引起胆石症和胆石症手术的文章。本文的目的是介绍儿童胆石病发病机制的最新研究。本文讨论了目前已知的所有因素对胆石病发展的影响，如遗传易感性、年龄、感染、使用的药物、肠外营养和合并症。儿童胆石症的病程复杂，从无症状到危及生命不等。了解疾病的病程和易患因素可以更快地诊断疾病并给予适当的治疗。
