Inflammatory Mechanism of Infection in Placental Trophoblast Cells.

Brucellosis is a severe zoonotic infectious disease caused by the infection of the , which is widespread and causes considerable economic losses in underdeveloped areas. is a facultative intracellular bacteria whose main target cells for infection are macrophages, placental trophoblast cells and dendritic cells. The main clinical signs of infection in livestock are reproductive disorders and abortion. At present, the pathogenesis of placentitis or abortion caused by in livestock is not fully understood, and further research on the effect of on placental development is still necessary. This review will mainly introduce the research progress of infection of placental trophoblast cells as well as the inflammatory response caused by it, explaining the molecular regulation mechanism of leading to reproductive system disorders and abortion, and also to provide the scientific basis for revealing the pathogenesis and infection mechanism of .