Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, CNRS UMR 9017-Inserm U1019, University Lille, 59019 Lille, France.
Int J Mol Sci. 2022 Nov 3;23(21):13457. doi: 10.3390/ijms232113457.
Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord tissues where it acts as a key cytokine to coordinate the exchange between the immune and central nervous system (CNS). In this review, we report the recent advances to our knowledge regarding the role of IL-33 and of its receptor ST2 in cerebral malaria, and in particular, we highlight the pivotal role that IL-33/ST2 signaling pathway could play in brain and cerebrospinal barriers permeability. IL-33 serum levels are significantly higher in children with severe malaria than children without complications or noninfected children. IL-33 levels are correlated with parasite load and strongly decrease with parasite clearance. We postulate that sequestration of infected erythrocytes or merozoites liberation from schizonts could amplify IL-33 production in endothelial cells, contributing either to malaria pathogenesis or recovery.
白细胞介素 33（IL-33）是一种免疫调节细胞因子，在组织功能和免疫介导的疾病中发挥关键作用。IL-33 在大脑和脊髓组织中含量丰富，作为一种关键细胞因子，协调免疫和中枢神经系统（CNS）之间的物质交换。在这篇综述中，我们报告了最近关于白细胞介素 33 和其受体 ST2 在脑疟疾中的作用的知识进展，特别是我们强调了 IL-33/ST2 信号通路在脑和脑脊液屏障通透性中的关键作用。与没有并发症的儿童或未感染的儿童相比，患有严重疟疾的儿童血清中白细胞介素 33 水平显著升高。白细胞介素 33 水平与寄生虫载量相关，并随着寄生虫清除而强烈下降。我们推测，感染红细胞的隔离或裂殖子从裂殖体的释放可能会增加内皮细胞中白细胞介素 33 的产生，这有助于疟疾的发病机制或恢复。
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