State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China.
Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China.
Int J Mol Sci. 2022 Nov 5;23(21):13583. doi: 10.3390/ijms232113583.
The intestinal tract is the most important location for symbiotes and pathogens, and the microbiota plays a crucial role in affecting the health of the gut and other host organs. Dysbacteriosis in the intestinal system has been proven to be significant in skin ulceration syndrome (SUS) in sea cucumbers. This study investigates whether the gut microbiota and lipid metabolites are relevant to the initiation and progression of SUS in a -infected sea cucumber model. The tight junction genes were downregulated and the inflammatory factor gene transcriptions were upregulated after infection in the intestinal tissue of the sea cucumber. infection modulated the gut microbiota by interacting with , , , and . Meanwhile, the metabolites of the long-chain fatty acids in the intestinal tissue, including triglycerides (TG), phosphatidylethanolamines (PE), and phosphatidylglycerols (PG), were altered after infection. engaged in positive interactions with PG and PE and negative interactions with specific TG. These results related to gut microbiota and metabolites can offer practical assistance in the identification of the inflammatory mechanisms related to SUS, and this study may serve as a reference for predicting the disease.
肠道是共生体和病原体最重要的栖息地，微生物群在影响肠道和其他宿主器官健康方面起着至关重要的作用。肠道系统的细菌失调已被证明与海参皮肤溃疡综合征（SUS）显著相关。本研究探讨了肠道微生物群和脂质代谢物是否与感染模型中海参 SUS 的发生和发展有关。在感染后，海参肠道组织中的紧密连接基因下调，炎症因子基因转录物上调。感染通过与 、 、 、 相互作用来调节肠道微生物群。同时，肠道组织中长链脂肪酸的代谢物，包括甘油三酯（TG）、磷脂酰乙醇胺（PE）和磷脂酰甘油（PG），在 感染后发生改变。与 PG 和 PE 呈正相互作用，与特定的 TG 呈负相互作用。这些与肠道微生物群和代谢物相关的结果可以为鉴定与 SUS 相关的炎症机制提供实际帮助，本研究可为疾病预测提供参考。
