Russu Octav, Bloj Florin, Feier Andrei Marian, Vunvulea Vlad, Mogoș Stefan, Predescu Vlad, Pop Tudor Sorin
Department of Orthopaedics and Traumatology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania.
Ares Excellence Center, Monza Oncological Hospital, 013812 Bucharest, Romania.
J Clin Med. 2022 Nov 5;11(21):6573. doi: 10.3390/jcm11216573.
Transarterial embolization (TAE) of genicular artery branches is a relatively new technique that has emerged as a promising method for delaying invasive knee surgery in patients suffering from degenerative knee osteoarthritis (OA). In mild to moderate OA, invasive major surgery can be safely postponed, and patients with major risk factors now have an alternative. Our aim was to examine the impact of TAE on clinical outcomes in individuals with degenerative knee OA over a 12-month period.
A case series of 17 patients diagnosed with knee OA and treated with TAE was included in the study. Every patient was clinically evaluated at different timeframes according to the Western Ontario and McMaster Universities' arthritis index, knee injury, and osteoarthritis outcome scores, and the 36-item short-form survey (WOMAC, KOOS, and SF-36).
At the first follow-up (1 month), KOOS and WOMAC improved from 46.6 ± 13.2 (range 27.3-78.2) to 56.5 ± 13.9 (range 32.3-78.4; = 0.023) and 49.5 ± 13.2 (range 29.3-82.3) to 59.8 ± 12.6 (range 39.3-83.5, = 0.018), respectively. Physical SF-36 improved significantly from 42.1 ± 7.75 (range 30.3-57.3) to 50.5 ± 9.9 (range 35.6-67.9; = 0.032). No significant changes in scores were observed at three, six, or twelve months after TAE.
TAE provided early pain reduction and considerable improvement in quality of life without complications for a consecutive sample of Romanian patients with mild to severe knee OA.
膝动脉分支的经动脉栓塞术（TAE）是一种相对较新的技术，已成为延缓退行性膝骨关节炎（OA）患者进行侵入性膝关节手术的一种有前景的方法。在轻度至中度OA中，可以安全地推迟侵入性大手术，现在有主要危险因素的患者有了一种替代选择。我们的目的是在12个月期间检查TAE对退行性膝OA患者临床结局的影响。
本研究纳入了17例诊断为膝OA并接受TAE治疗的患者的病例系列。根据西安大略和麦克马斯特大学关节炎指数、膝关节损伤和骨关节炎结局评分以及36项简短调查（WOMAC、KOOS和SF-36），在不同时间框架对每位患者进行临床评估。
在首次随访（1个月）时，KOOS和WOMAC分别从46.6±13.2（范围27.3 - 78.2）提高到56.5±13.9（范围32.3 - 78.4；P = 0.023）以及从49.5±13.2（范围29.3 - 82.3）提高到59.8±12.6（范围39.3 - 83.5，P = 0.018）。身体方面的SF-36从42.1±7.75（范围30.3 - 57.3）显著提高到50.5±9.9（范围35.6 - 67.9；P = 0.032）。TAE后3个月、6个月或12个月时，评分未观察到显著变化。
对于罗马尼亚轻度至重度膝OA的连续样本患者，TAE可早期减轻疼痛并显著改善生活质量，且无并发症。
