Kotlyarov Stanislav, Kotlyarova Anna
Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Department of Pharmacy Management and Economics, Ryazan State Medical University, 390026 Ryazan, Russia.
Membranes (Basel). 2022 Oct 24;12(11):1036. doi: 10.3390/membranes12111036.
Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of patients. Atherosclerosis is a complex chain of events, which proceeds over many years and in which many cells in the bloodstream and the vascular wall are involved. A growing body of evidence suggests that there are complex, closely linked molecular mechanisms that occur in the plasma membranes of cells involved in atherogenesis. Lipid transport, innate immune system receptor function, and hemodynamic regulation are linked to plasma membranes and their biophysical properties. A better understanding of these interrelationships will improve diagnostic quality and treatment efficacy.
动脉粥样硬化性心血管疾病是一个重要的医学问题，因其患病率高、对生活质量和预后有影响。动脉粥样硬化的发病机制是一个紧迫的医学和社会问题，解决这一问题可能会改善患者的诊断和治疗质量。动脉粥样硬化是一系列复杂的事件，其过程持续多年，涉及血液和血管壁中的许多细胞。越来越多的证据表明，在动脉粥样硬化发生过程中涉及的细胞的质膜中存在复杂且紧密相连的分子机制。脂质转运、先天性免疫系统受体功能和血流动力学调节与质膜及其生物物理特性相关。更好地理解这些相互关系将提高诊断质量和治疗效果。
