Parshina Anna, Yelnikova Anastasia, Safronova Ekaterina, Kоlganova Tatyana, Kuleshova Victoria, Bobreshova Olga, Yaroslavtsev Andrey
Department of Analytical Chemistry, Voronezh State University, 394018 Voronezh, Russia.
Kurnakov Institute of General and Inorganic Chemistry RAS, 119991 Moscow, Russia.
Membranes (Basel). 2022 Nov 2;12(11):1091. doi: 10.3390/membranes12111091.
Sulfamethoxazole and trimethoprim are synthetic bacteriostatic drugs. A potentiometric multisensory system for the analysis of sulfamethoxazole and trimethoprim combination drugs was developed. Perfluorosulfonic acid membranes containing functionalized CNTs were used as the sensor materials. The CNTs' surface was modified by carboxyl, sulfonic acid, or (3-aminopropyl)trimethoxysilanol groups. The influence of the CNT concentration and the properties of their surface, as well as preliminary ultrasonic treatment of the polymer and CNT solution before the casting of hybrid membranes, on their ion-exchange capacity, water uptake, and transport properties was revealed. Cross-sensitivity of the sensors to the analytes was achieved due to ion exchange and hydrophobic interactions with hybrid membranes. An array of cross-sensitive sensors based on the membranes containing 1.0 wt% of CNTs with sulfonic acid or (3-aminopropyl)trimethoxysilanol groups enabled us to provide the simultaneous determination of sulfamethoxazole and trimethoprim in aqueous solutions with a concentration ranging from 1.0 × 10 to 1.0 × 10 M (pH 4.53-8.31). The detection limits of sulfamethoxazole and trimethoprim were 3.5 × 10 and 1.3 × 10 М. The relative errors of sulfamethoxazole and trimethoprim determination in the combination drug as compared with the content declared by the manufacturer were 4% (at 6% RSD) and 5% (at 7% RSD).
磺胺甲恶唑和甲氧苄啶是合成抑菌药物。开发了一种用于分析磺胺甲恶唑和甲氧苄啶复方药物的电位多传感系统。含有功能化碳纳米管的全氟磺酸膜被用作传感材料。碳纳米管的表面通过羧基、磺酸或（3-氨丙基）三甲氧基硅烷基团进行了改性。揭示了碳纳米管浓度及其表面性质，以及在浇铸混合膜之前对聚合物和碳纳米管溶液进行的初步超声处理，对其离子交换容量、吸水率和传输性能的影响。由于离子交换以及与混合膜的疏水相互作用，传感器对分析物实现了交叉敏感性。基于含有1.0 wt%磺酸或（3-氨丙基）三甲氧基硅烷基团的碳纳米管的膜的交叉敏感传感器阵列，使我们能够同时测定浓度范围为1.0×10至1.0×10 M（pH 4.53 - 8.31）的水溶液中的磺胺甲恶唑和甲氧苄啶。磺胺甲恶唑和甲氧苄啶的检测限分别为3.5×10和1.3×10 М。与制造商声明的含量相比，复方药物中磺胺甲恶唑和甲氧苄啶测定的相对误差分别为4%（相对标准偏差为6%）和5%（相对标准偏差为7%）。
