Parshina Anna, Yelnikova Anastasia, Kolganova Tatyana, Titova Tatyana, Yurova Polina, Stenina Irina, Bobreshova Olga, Yaroslavtsev Andrey
Department of Analytical Chemistry, Voronezh State University, 394018 Voronezh, Russia.
Kurnakov Institute of General and Inorganic Chemistry RAS, 119991 Moscow, Russia.
Membranes (Basel). 2023 Mar 8;13(3):311. doi: 10.3390/membranes13030311.
A novel potentiometric multisensory system for the analysis of sulfamethoxazole and trimethoprim combination drugs was developed. The potentiometric sensors (Donnan potential (DP) was used as an analytical signal) with an inner reference solution were based on perfluorosulfonic acid (PFSA) membranes modified with polyaniline (PANI) by in situ oxidative polymerization. The order of the membrane treatment with precursor solutions and their concentrations was varied. Additionally, the PFSA/PANI composite membranes were hydrothermally treated at 120 °C. The influence of the preparation conditions and the composition of membranes on their sorption and transport properties was studied. We estimated the factors affecting the sensitivity of DP-sensors based on the PFSA/PANI composite membranes to ions of sulfamethoxazole and trimethoprim simultaneously presented in solutions. A developed multisensory system provided a simultaneous determination of two analytes in aqueous solutions without preliminary separation, derivatization, or probe treatment. The re-estimation of the calibration characteristics of the multisensory system did not show a statistically significant difference after a year of its use. The limits of detection of sulfamethoxazole and trimethoprim were 1.4 × 10 and 8.5 × 10 M, while the relative errors of their determination in the combination drug were 4 and 5% (at 5 and 6% relative standard deviation), respectively.
开发了一种用于分析磺胺甲恶唑和甲氧苄啶复方药物的新型电位多传感系统。电位传感器（以唐南电位（DP）作为分析信号）带有内参比溶液，基于通过原位氧化聚合用聚苯胺（PANI）改性的全氟磺酸（PFSA）膜。前驱体溶液及其浓度的膜处理顺序有所不同。此外，PFSA/PANI复合膜在120℃下进行水热处理。研究了制备条件和膜组成对其吸附和传输性能的影响。我们估计了基于PFSA/PANI复合膜的DP传感器对溶液中同时存在的磺胺甲恶唑和甲氧苄啶离子灵敏度的影响因素。所开发的多传感系统无需预分离、衍生化或探针处理即可同时测定水溶液中的两种分析物。多传感系统使用一年后，其校准特性的重新评估未显示出统计学上的显著差异。磺胺甲恶唑和甲氧苄啶的检测限分别为1.4×10和8.5×10 M，而它们在复方药物中测定的相对误差分别为4%和5%（相对标准偏差为5%和6%）。
