"一锅法"CuCl 介导的缩合/C-S 键偶联反应通过双功能试剂 N, N'-二甲乙二胺合成二苯并噻嗪
"One-Pot" CuCl-Mediated Condensation/C-S Bond Coupling Reactions to Synthesize Dibenzothiazepines by Bi-Functional-Reagent N, N'-Dimethylethane-1,2-Diamine.
机构信息
School of Chemistry and Chemical Engineering, Liaocheng University, 1 Hunan Avenue, Liaocheng 252000, China.
Zhejiang Heze Pharmaceutical Technology, 1 Street, Qiantang New District, Hangzhou 310018, China.
出版信息
Molecules. 2022 Oct 31;27(21):7392. doi: 10.3390/molecules27217392.
The efficient "One-pot" CuCl-catalyzed C-S bond coupling reactions were developed for the synthesis of dibenzo[,][1,4]thiazepines and 11-methy-ldibenzo[,][1,4]thiazepines via 2-iodobenzaldehydes/2-iodoacetophenones with 2-aminobenzenethiols/2,2'-disulfanediyldianilines by using bifunctional-reagent N, N'-dimethylethane-1,2-diamine (DMEDA), which worked as ligand and reductant. The reactions were compatible with a range of substrates to give the corresponding products in moderate to excellent yields.
高效的“一锅法”CuCl 催化 C-S 键偶联反应被开发出来，用于通过 2-碘苯甲醛/2-碘苯乙酮与 2-氨基苯硫醇/2,2'-二硫二苯胺，以双官能试剂 N, N'-二甲乙二胺 (DMEDA) 作为配体和还原剂，合成二苯并[,][1,4]噻嗪和 11-甲基二苯并[,][1,4]噻嗪。该反应与一系列底物兼容，以中等至优异的收率得到相应产物。
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