Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via P. Gaifami 18, 95126 Catania, Italy.
Department of Agricultural, Food and Forest Sciences, University of Palermo, Viale delle Scienze, Build 4, Entr. L, 90128 Palermo, Italy.
Molecules. 2022 Nov 1;27(21):7427. doi: 10.3390/molecules27217427.
Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and superoxide dismutase mimetic activity of the samples under study were measured. Moreover, to investigate the anti-inflammatory activity of the DWWs, an in vitro experimental model of intestinal inflammation was used. The DWW samples' phytochemical analysis allowed the identification of 37 phenolic compounds, all exhibiting good antioxidant and anti-inflammatory activity. Our study contributes to the knowledge on the polyphenolic composition of the DWWs of five aromatic plants of the Lamiaceae family. The results highlight the presence of compounds with proven biological activity, and therefore of great interest in the pharmaceutical and nutraceutical fields.
蒸馏是从植物材料中提取精油最广泛使用的方法。在该过程中使用的生物质作为固体残余物返回，其中含有不同量的富含水溶性化合物的水，目前这些水尚未应用于任何进一步的用途。本工作的目的是评估五种属于唇形科的芳香植物水蒸馏（DWW）废水的植物化学成分，并评估它们的体外抗氧化和抗炎活性。通过 HPLC-DAD 和 HPLC-ESI/MS 测定 DWW 的酚类图谱。研究了样品的自由基清除能力、氧自由基抗氧化能力和超氧化物歧化酶模拟活性。此外，为了研究 DWW 的抗炎活性，使用了一种体外肠道炎症实验模型。DWW 样品的植物化学分析鉴定出 37 种酚类化合物，均表现出良好的抗氧化和抗炎活性。本研究有助于了解唇形科五种芳香植物的 DWW 的多酚组成。结果突出了具有已证实生物活性的化合物的存在，因此在制药和营养保健品领域具有很大的兴趣。
