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从 和 的根部分离得到的 8 种吲哚生物碱及其对一氧化氮的抑制作用。

Eight Indole Alkaloids from the Roots of and Their Nitric Oxide Inhibitory Effects.

机构信息

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Natural Products and Nanoparticles Research Unit, Chulalongkorn University, Bangkok 10330, Thailand.

出版信息

Molecules. 2022 Nov 4;27(21):7558. doi: 10.3390/molecules27217558.

DOI:10.3390/molecules27217558
PMID:36364385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9656735/
Abstract

(Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A-C, and maeruabisindoles A-C, were isolated from them. Spectroscopic methods and computational analysis were applied to determine the structure of the isolated compounds. Maeroximes A-C possesses an unusual O-methyloxime moiety. The bisindole alkaloid maeruabisindoles A and B possess a rare azete ring, whereas maeruabisindole C is the first indolo[3,2-]carbazole derivative found in this plant family. Five compounds [maeruanitriles A and B, maeroxime C, maeruabisindoles B, and C] displayed anti-inflammatory activity by inhibiting nitric oxide (NO) production in the lipopolysaccharide-induced RAW 264.7 cells. Maeruabisindole B was the most active inhibitor of NO production, with an IC of 31.1 ± 1.8 μM compared to indomethacin (IC = 150.0 ± 16.0 μM) as the positive control.

摘要

（山柑科）根用于治疗疼痛和炎症在传统的泰国医学。八新吲哚生物碱，命名为 maeruanitriles A 和 B，maeroximes A-C 和 maeruabisindoles A-C，从他们中分离出来。光谱方法和计算分析被应用于确定分离化合物的结构。Maeroximes A-C 具有不寻常的 O-甲肟部分。双吲哚生物碱 maeruabisindoles A 和 B 具有罕见的 azete 环，而 maeruabisindole C 是第一个在这个植物家族中发现的吲哚[3,2-]咔唑衍生物。五种化合物 [maeruanitriles A 和 B、maeroxime C、maeruabisindoles B 和 C] 通过抑制脂多糖诱导的 RAW 264.7 细胞中一氧化氮 (NO) 的产生显示出抗炎活性。Maeruabisindole B 是最有效的一氧化氮产生抑制剂，IC 为 31.1 ± 1.8 μM，而吲哚美辛（IC = 150.0 ± 16.0 μM）作为阳性对照。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/b0cd868e2e94/molecules-27-07558-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/623735c295f8/molecules-27-07558-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/1bd9ad1e909b/molecules-27-07558-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/5acc687481ae/molecules-27-07558-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/0720341ee738/molecules-27-07558-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/9558a922fd0e/molecules-27-07558-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/b0cd868e2e94/molecules-27-07558-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/623735c295f8/molecules-27-07558-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/1bd9ad1e909b/molecules-27-07558-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/5acc687481ae/molecules-27-07558-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/0720341ee738/molecules-27-07558-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/9558a922fd0e/molecules-27-07558-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7502/9656735/b0cd868e2e94/molecules-27-07558-g006.jpg

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