从 的根部分离得到具有抑制一氧化氮活性的生物碱。
Alkaloids with Nitric Oxide Inhibitory Activities from the Roots of .
机构信息
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Institute of TCM International Standardization of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Molecules. 2019 Nov 7;24(22):4033. doi: 10.3390/molecules24224033.
As our ongoing research project on Ban Lan Gen ( roots), a total of 23 alkaloids were obtained. Compounds and contain an unusual C-C bond between the 2(1)-quinolinone moiety and the phenol moiety and between the 2(1)-quinolinone moiety and the 1-indole moiety, respectively. Compound possesses an unusual carbon skeleton and its putative biosynthetic pathway was discussed, and Compound was deduced as a new indole alkaloid glycoside. Compounds were identified as four new natural products by extensive spectroscopic experiments. Additionally, the anti-inflammatory activity was assessed based on nitric oxide (NO) production using Lipopolysaccharide-stimulated RAW264.7 macrophages. Compounds , and showed inhibitory effects with IC values of 1.2, 5.0, and 74.4 μM.
作为我们正在进行的板蓝根（根）研究项目，共获得了 23 种生物碱。化合物和含有在 2(1)-喹啉酮部分和酚部分之间以及在 2(1)-喹啉酮部分和 1-吲哚部分之间不寻常的 C-C 键。化合物具有不寻常的碳骨架，讨论了其可能的生物合成途径，化合物被推断为一种新的吲哚生物碱糖苷。通过广泛的光谱实验，将化合物鉴定为四种新的天然产物。此外，基于脂多糖刺激的 RAW264.7 巨噬细胞中一氧化氮（NO）的产生来评估抗炎活性。化合物、和表现出抑制作用，IC 值分别为 1.2、5.0 和 74.4 μM。
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