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功能性寡糖在肠道疾病治疗中的研究现状与应用前景

Recent Research and Application Prospect of Functional Oligosaccharides on Intestinal Disease Treatment.

机构信息

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

出版信息

Molecules. 2022 Nov 7;27(21):7622. doi: 10.3390/molecules27217622.

Abstract

The intestinal tract is an essential digestive organ of the human body, and damage to the intestinal barrier will lead to various diseases. Functional oligosaccharides are carbohydrates with a low degree of polymerization and exhibit beneficial effects on human intestinal health. Laboratory experiments and clinical studies indicate that functional oligosaccharides repair the damaged intestinal tract and maintain intestinal homeostasis by regulating intestinal barrier function, immune response, and intestinal microbial composition. Functional oligosaccharides treat intestinal disease such as inflammatory bowel disease (IBD) and colorectal cancer (CRC) and have excellent prospects for therapeutic application. Here, we present an overview of the recent research into the effects of functional oligosaccharides on intestinal health.

摘要

肠道是人体的重要消化器官,肠道屏障损伤会导致多种疾病。功能性低聚糖是一种低聚合度的碳水化合物,对人体肠道健康具有有益作用。实验室实验和临床研究表明,功能性低聚糖通过调节肠道屏障功能、免疫反应和肠道微生物组成来修复受损的肠道并维持肠道内环境稳态。功能性低聚糖可治疗炎症性肠病(IBD)和结直肠癌(CRC)等肠道疾病,具有很好的治疗应用前景。本文对功能性低聚糖对肠道健康影响的研究进展进行综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d69/9656564/d3de7355649b/molecules-27-07622-g001.jpg

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