Sustainable Technology Laboratories, Asahi Quality & Innovations, Ltd., 1-21, Midori 1-Chome, Moriya-shi 302-0106, Ibaraki, Japan.
Nutrients. 2022 Oct 26;14(21):4502. doi: 10.3390/nu14214502.
The change in physiological parameters and subjective feelings according to the speed of drinking alcohol has not been reported to date. The aim of this randomized crossover pilot study was to investigate the objective and subjective effects of different speeds of alcohol ingestion in healthy volunteers. Accordingly, 11 male and 7 female healthy Japanese adults were asked to consume 480 mL of beer at three different drinking speeds (80, 40, and 20 mL/5 min). According to the objective measurement, the transient increase in blood alcohol and serum uric acid concentrations was most inhibited at a drinking speed of 20 mL/5 min. Acetate, lactate, pyruvate, and lactate/pyruvate ratios did not differ between the three drinking speeds. Stimulant feelings measured by the subjective scores of the Brief Biphasic Alcohol Effects Scale did not differ between the three speeds. However, the sedative feeling score obtained at a drinking speed of 20 mL/5 min (the slowest speed of alcohol consumption) was significantly weakened in comparison with those obtained at drinking speeds of 40 and 80 mL/5 min. Therefore, a slower consumption of alcohol mitigated the subjective sedative feeling. The effects of slower alcohol consumption may be caused by the slower slope of the increasing trend of blood alcohol concentration.
目前尚未报道根据饮酒速度变化的生理参数和主观感受的变化。本随机交叉先导研究的目的是调查健康志愿者不同饮酒速度的客观和主观影响。因此，11 名男性和 7 名女性日本健康成年人被要求以三种不同的饮酒速度（80、40 和 20 毫升/5 分钟）饮用 480 毫升啤酒。根据客观测量，在 20 毫升/5 分钟的饮酒速度下，血液酒精和血清尿酸浓度的短暂升高受到的抑制最明显。三种饮酒速度之间的乙酸盐、乳酸盐、丙酮酸和乳酸/丙酮酸比值没有差异。通过简短双相酒精效应量表的主观评分测量的兴奋剂感觉在三种速度之间没有差异。然而，以 20 毫升/5 分钟（饮酒速度最慢）的速度饮酒时获得的镇静感评分与以 40 和 80 毫升/5 分钟的速度饮酒时获得的评分相比显著减弱。因此，较慢的饮酒速度减轻了主观镇静感。较慢的酒精消耗的影响可能是由于血液酒精浓度增加趋势的斜率较慢所致。
