Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, Taiwan.
Nutrients. 2022 Oct 30;14(21):4563. doi: 10.3390/nu14214563.
Excessive, high-intensity or inappropriate exercise may cause muscle damage. How to speed up recovery and reduce exercise discomfort are currently very important issues for athletes and sports people. Past research has shown that probiotics can improve inflammation and oxidative stress, as well as improve exercise performance and antifatigue. However, further research is needed to confirm the recovery benefits for muscle damage. In this double-blind design study, all subjects were randomly assigned to placebo, a live Lactobacillus paracasei group (L-PS23, 2 × 1010 colony forming unit (CFU)/day), or a heat-killed L. paracasei group (HK-PS23, 2 × 1010 cells/day), and supplemented for six consecutive weeks. Afterwards, subjects completed 100 maximal vertical jumps to bring about exercise-induced muscle damage (EIMD). Countermovement jump (CMJ), isometric mid-thigh pull (IMTP), and Wingate anaerobic test (WAnT), as well as blood tests for markers of muscle damage and inflammation were made pre-exercise and 3, 24, 48 h post exercise. The results show that both L-PS23 and HK-PS23 supplementation significantly slowed the loss of muscle strength after muscle injury, and they significantly reduced the production of markers of muscle damage and inflammation (p < 0.05). In addition, L-PS23 and HK-PS23 had the benefits of accelerating the recovery and improvement of muscle strength, the blood markers of muscle injury and inflammation, and slowing the decline in testosterone concentrations (p < 0.05). Especially in the HK-PS23 supplemented group, there was a better trend. In conclusion, we found that L-PS23 or HK-PS23 supplementation for six weeks prevented strength loss after muscle damage and improved blood muscle damage and inflammatory markers, with protective, accelerated recovery and anti-fatigue benefits.
过度、高强度或不适当的运动可能会导致肌肉损伤。如何加快恢复速度，减轻运动不适，是运动员和运动爱好者目前非常关注的问题。既往研究表明，益生菌可以改善炎症和氧化应激，提高运动表现和抗疲劳能力。但是，对于肌肉损伤的恢复作用，还需要更多的研究来证实。在这项双盲设计的研究中，所有受试者均被随机分配至安慰剂组、活性副干酪乳杆菌组（L-PS23，2×1010 菌落形成单位（CFU）/天）或热处理副干酪乳杆菌组（HK-PS23，2×1010 细胞/天），并连续补充 6 周。之后，受试者完成 100 次最大垂直跳跃，造成运动诱导的肌肉损伤（EIMD）。在运动前和运动后 3、24、48 h，进行了反跳式垂直跳跃（CMJ）、等长大腿中部拉伸（IMTP）和无氧功率测试（WAnT），并进行了血液标志物检测。结果表明，L-PS23 和 HK-PS23 补充剂均显著减缓了肌肉损伤后肌肉力量的丧失，显著降低了肌肉损伤和炎症标志物的产生（p<0.05）。此外，L-PS23 和 HK-PS23 具有加速肌肉力量恢复和改善的作用，能够降低肌肉损伤和炎症的血液标志物，减缓睾酮浓度的下降（p<0.05）。尤其是在补充 HK-PS23 的组中，这种趋势更为明显。总之，我们发现，补充 L-PS23 或 HK-PS23 6 周可预防肌肉损伤后的力量损失，改善血液肌肉损伤和炎症标志物，具有保护、加速恢复和抗疲劳的作用。
