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SDSP202418对小鼠运动性疲劳的缓解作用。

Alleviating effect of SDSP202418 on exercise-induced fatigue in mice.

作者信息

Yang Yang, Zhao Yuanji, Lei Huan

机构信息

College of Physical Education, Chengdu Sport University, Chengdu, China.

School of Physical Education, Wuhan Sports University, Wuhan, China.

出版信息

Front Microbiol. 2024 Sep 26;15:1420872. doi: 10.3389/fmicb.2024.1420872. eCollection 2024.

DOI:10.3389/fmicb.2024.1420872
PMID:39391603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11464290/
Abstract

In this study, the effects of SDSP202418 isolated from shrimp paste on the exercise performance of fatigued mice were analyzed, and the potential action mechanism was revealed. SDSP202418 significantly improved the exhaustion time of the mice and regulated the biochemical indices (lactate dehydrogenase, nitrogen, and uric acid) of the fatigued mice to resist fatigue. SDSP202418 also upregulated the mRNA expression of slow muscle fibers and downregulated the mRNA expression of fast muscle fibers in the exercise mice by activating the AMPK/PGC-1α pathway in the fatigued mice. It also increased the contents of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)) in the liver and muscle. These enzymes removed and repaired oxidative free radicals to achieve antifatigue. In addition, SDSP202418 can change the gut microbial structure and modulate the abundance and balance of fatigue-related gut microbiota, which in turn exerts antifatigue effects. SDSP202418 is a functional food component that relieves fatigue after exercise.

摘要

本研究分析了从虾酱中分离出的SDSP202418对疲劳小鼠运动能力的影响，并揭示了其潜在作用机制。SDSP202418显著延长了小鼠的力竭时间，并调节了疲劳小鼠的生化指标（乳酸脱氢酶、氮和尿酸）以抵抗疲劳。SDSP202418还通过激活疲劳小鼠的AMPK/PGC-1α通路，上调了运动小鼠慢肌纤维的mRNA表达，下调了快肌纤维的mRNA表达。它还增加了肝脏和肌肉中抗氧化酶（超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽（GSH））的含量。这些酶清除并修复氧化自由基以实现抗疲劳。此外，SDSP202418可以改变肠道微生物结构，调节与疲劳相关的肠道微生物群的丰度和平衡，进而发挥抗疲劳作用。SDSP202418是一种缓解运动后疲劳的功能性食品成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/9b3385842f2a/fmicb-15-1420872-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/5f7f87596fca/fmicb-15-1420872-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/9b3385842f2a/fmicb-15-1420872-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/4414fcb85be3/fmicb-15-1420872-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/107b46369edc/fmicb-15-1420872-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/318e6df3cefb/fmicb-15-1420872-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/b5645abdc0b8/fmicb-15-1420872-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/ffa9eb610798/fmicb-15-1420872-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/d7f734a8685d/fmicb-15-1420872-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/b2f990e0d660/fmicb-15-1420872-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/29d0fd5ca357/fmicb-15-1420872-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/22cbf3e30888/fmicb-15-1420872-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/5bf7a52be732/fmicb-15-1420872-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/98fb98588e8a/fmicb-15-1420872-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1165/11464290/9b3385842f2a/fmicb-15-1420872-g013.jpg

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