National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, Beijing 100050, China.
Nutrients. 2022 Nov 1;14(21):4580. doi: 10.3390/nu14214580.
Although several studies have shown the relationship between magnesium and diabetes, there are few studies regarding the association between magnesium status and prediabetes. This study aimed to examine the association between dietary magnesium intake and the risk of prediabetes in childbearing Chinese women (18−44 years). A total of 1981 participants without diabetes were randomly selected from China Nutrition and Health Surveillance (CNHS) in 2015 by considering the regional types and monitoring points, including 1420 normal fasting glucose (NFG) people and 561 prediabetes cases. The Food Frequency Questionnaire (FFQ) and inductively coupled plasma mass spectrometry (ICP-MS) measured dietary and plasma magnesium. The results of this study showed that dietary magnesium intake was inversely associated with fasting plasma glucose. For every 100 mg of magnesium intake, there was a 0.052 mmol/L (95% CI 0.019, 0.085) reduction in fasting plasma glucose (p = 0.002). Compared with the lowest intake quartile (<350.10 mg/day), the third and fourth quartiles (≥405.41 mg/day) reduced the odds risk of prediabetes (OR = 0.63, 95% CI 0.46, 0.88, p = 0.020) by approximately 37%. The dose-response curves for the association between magnesium intake and prediabetes followed an L shape. The odds ratio of prediabetes decreased significantly with increasing dietary Mg intake at less than 410 mg/day, and then the curve leveled off or slightly increased. This study found a negative association between dietary magnesium intake and prediabetes in childbearing Chinese women. The risk of prediabetes was reduced with increasing dietary magnesium intake, and the threshold value was 410 mg/day. This suggests that childbearing women also need to pay attention to their magnesium status.
尽管已有多项研究表明镁与糖尿病之间存在关联，但关于镁状态与糖尿病前期之间的关联的研究却很少。本研究旨在探讨中国育龄期妇女（18-44 岁）膳食镁摄入量与糖尿病前期风险之间的关系。考虑到区域类型和监测点，我们于 2015 年从中国营养与健康监测（CNHS）中随机抽取了 1981 名无糖尿病的参与者，其中包括 1420 名空腹血糖正常（NFG）人群和 561 名糖尿病前期病例。通过食物频率问卷（FFQ）和电感耦合等离子体质谱法（ICP-MS）来测量膳食和血浆镁。本研究结果表明，膳食镁摄入量与空腹血糖呈负相关。每增加 100mg 镁的摄入量，空腹血糖就会降低 0.052mmol/L（95%CI 0.019，0.085）（p=0.002）。与最低摄入量四分位数（<350.10mg/天）相比，第三和第四四分位数（≥405.41mg/天）降低了糖尿病前期的患病风险（OR=0.63，95%CI 0.46，0.88，p=0.020）约 37%。镁摄入量与糖尿病前期之间的剂量反应曲线呈 L 型。随着膳食 Mg 摄入量的增加，糖尿病前期的比值比显著降低，当摄入量小于 410mg/天，之后曲线趋于平稳或略有上升。本研究发现，中国育龄期妇女的膳食镁摄入量与糖尿病前期呈负相关。随着膳食镁摄入量的增加，糖尿病前期的患病风险显著降低，而阈值为 410mg/天。这表明，育龄妇女也需要关注自身的镁状况。
