Department of Anesthesiology, Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital, Chengdu, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
J Int Med Res. 2022 Nov;50(11):3000605221132466. doi: 10.1177/03000605221132466.
Ciprofol is a novel intravenous anesthetic agent and a highly selective gamma-aminobutyric acid-A receptor agonist, similar to propofol. This is the first report about ciprofol overdose occurring during the maintenance phase of anesthesia for a surgical intervention. The accidental administration of an excessive ciprofol dose to a 37-year-old woman admitted to our hospital for laparoscopic myomectomy occurred during the first 3 minutes of maintenance anesthesia, in which the administered dose was 3.67 mg/kg instead of 0.06 mg/kg. The patient's bispectral index (BIS) decreased to 0 after 6 minutes and returned to 26 after 23 minutes, after which the surgery was restarted and successfully completed with the planned ciprofol maintenance anesthesia dose. During the 23 minutes after ciprofol overdose, the patient's vital signs were stable with the lowest mean arterial pressure being 69.3 mmHg. The patient regained consciousness quickly and recovered well after myomectomy. The patient's BIS decreased progressively, whereas her blood pressure, heart rate, and oxygen saturation did not change significantly. In the present case of ciprofol overdose, the observed stable blood pressure protected against organ injury during laparoscopic myomectomy.
西普罗夫是一种新型的静脉麻醉剂，是一种高度选择性的γ-氨基丁酸-A 受体激动剂，类似于丙泊酚。这是首例报道的在手术麻醉维持阶段发生西普罗夫过量的病例。一位 37 岁的女性因腹腔镜子宫肌瘤切除术被收入我院，在维持麻醉的最初 3 分钟内，意外给予了过量的西普罗夫（3.67mg/kg，而非 0.06mg/kg）。6 分钟后，患者的脑电双频指数（BIS）降至 0，23 分钟后恢复至 26，随后手术以计划的西普罗夫维持麻醉剂量重新开始并成功完成。西普罗夫过量后 23 分钟内，患者的生命体征稳定，最低平均动脉压为 69.3mmHg。患者术后很快恢复意识，子宫肌瘤切除术后恢复良好。患者的 BIS 逐渐下降，而血压、心率和血氧饱和度没有明显变化。在本病例中，西普罗夫过量时观察到的血压稳定，防止了腹腔镜子宫肌瘤切除术中的器官损伤。
