Devaraj Rashmi, Shafi Peerzada, Nagesh Chinmay, Naidu Amar, Satishchandra Parthasarathy
Department of Neurology, Apollo Specialty Hospital, Jayanagar, Bengaluru, India.
Department of Neuro-radiology, Apollo Specialty Hospital, Jayanagar, Bengaluru, India.
J Clin Neurol. 2022 Nov;18(6):681-691. doi: 10.3988/jcn.2022.18.6.681.
According to WHO statistics, approximately 6.9 billion people worldwide had been vaccinated against SARS-CoV-2 as at October 27, 2021, including around 1.0 billion people in India. Most Indian recipients received the Covishield (ChAdOx1-S/nCoV-19) vaccine, followed by the Covaxin (an inactivated SARS-CoV-2 antigen) vaccine. This study was conducted to characterize the neurological phenotypic spectrum of patients with adverse events following immunization with any of the available COVID-19 vaccines in India (Covishield or Covaxin) during the study period and their temporal relationship with vaccination.
This ambispective multicenter hospital-based cohort study covered the period from March to October 2021. The study included all cases suspected of having neurological complications following COVID-19 vaccination.
We report a spectrum of serious postvaccination neurological complications comprising primary central nervous system demyelination (4 cases), cerebral venous thrombosis (3 cases), Guillain-Barre syndrome (2 cases), vaccine-induced prothrombotic immune thrombocytopenia syndrome (2 cases), cranial nerve palsies (2 cases), primary cerebral hemorrhage (1 case), vestibular neuronitis (1 case), chronic inflammatory demyelinating polyneuropathy (1 case), generalized myasthenia (1 case), and seizures (1 case).
Although the benefits of vaccination far outweigh its risks, clinicians must be aware of possible serious adverse events associated with COVID-19 vaccinations.
根据世界卫生组织的统计数据，截至2021年10月27日，全球约有69亿人接种了新冠病毒疫苗，其中印度约有10亿人。大多数印度接种者接种的是Covishield（ChAdOx1-S/nCoV-19）疫苗，其次是Covaxin（一种灭活的新冠病毒抗原）疫苗。本研究旨在描述在研究期间印度使用任何一种可用的新冠病毒疫苗（Covishield或Covaxin）免疫后出现不良事件的患者的神经表型谱，以及这些事件与疫苗接种的时间关系。
这项回顾性多中心医院队列研究涵盖了2021年3月至10月期间。该研究纳入了所有疑似新冠病毒疫苗接种后出现神经并发症的病例。
我们报告了一系列严重的疫苗接种后神经并发症，包括原发性中枢神经系统脱髓鞘（4例）、脑静脉血栓形成（3例）、吉兰-巴雷综合征（2例）、疫苗诱导的血栓前免疫性血小板减少综合征（2例）、脑神经麻痹（2例）、原发性脑出血（1例）、前庭神经炎（1例）、慢性炎症性脱髓鞘性多发性神经病（1例）、全身性重症肌无力（1例）和癫痫发作（1例）。
尽管疫苗接种的益处远大于风险，但临床医生必须意识到与新冠病毒疫苗接种相关的可能严重不良事件。
