Department of Systems Biology, College of Bioinformatics Science and Technology, Harbin Medical University, Baojian Road, Nangang District, Harbin, Heilongjiang 150086, China.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Donghu Road, Wuchang District, Wuhan 430071, China.
Database (Oxford). 2022 Nov 11;2022. doi: 10.1093/database/baac095.
Fibrosis is a common and serious disease that exists as a complicated impairment in many organs and triggers a complex cascade of responses. The deregulation of Ribonucleic Acids (RNAs) plays important roles in a variety of organ fibrosis cases. However, for fibrotic diseases, there is still a lack of an integrated platform with up-to-date information on RNA deregulation and high-throughput data. The Fibrotic Disease-associated RNAome database (FDRdb) (http://www.medsysbio.org/FDRdb) is a manually curated database of fibrotic disease-associated RNAome information and high-throughput datasets. This initial release (i) contains 1947 associations between 912 RNAs and 92 fibrotic diseases in eight species; (ii) collects information on 764 datasets of fibrotic diseases; (iii) provides a user-friendly web interface that allows users to browse, search and download the RNAome information on fibrotic diseases and high-throughput datasets and (iv) provides tools to analyze the expression profiles of fibrotic diseases, including differential expression analysis and pathway enrichment. The FDRdb is a valuable resource for researchers to explore the mechanisms of RNA dysregulation in organ fibrosis. Database URL: http://www.medsysbio.org/FDRdb.
纤维化是一种常见且严重的疾病，存在于许多器官的复杂损伤中，并引发一系列复杂的反应。核糖核酸（RNAs）的失调在多种器官纤维化病例中起着重要作用。然而，对于纤维化疾病，仍然缺乏一个整合的平台，提供有关 RNA 失调的最新信息和高通量数据。纤维化疾病相关 RNA 组数据库（FDRdb）（http://www.medsysbio.org/FDRdb）是一个纤维化疾病相关 RNA 组信息和高通量数据集的手动整理数据库。这个初始版本（i）包含 1947 个 912 个 RNA 和 92 种纤维化疾病之间的关联，分布在 8 个物种中；（ii）收集了 764 个纤维化疾病数据集的信息；（iii）提供了一个用户友好的网络界面，允许用户浏览、搜索和下载纤维化疾病和高通量数据集的 RNA 组信息；（iv）提供了分析纤维化疾病表达谱的工具，包括差异表达分析和通路富集。FDRdb 是研究人员探索器官纤维化中 RNA 失调机制的有价值的资源。数据库网址：http://www.medsysbio.org/FDRdb。
