Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Virchhowweg 12, 10117 Berlin, Germany.
Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Virchhowweg 12, 10117 Berlin, Germany; Department for Gastroenterology, Infectious diseases, Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany.
Semin Immunol. 2022 Nov;61-64:101670. doi: 10.1016/j.smim.2022.101670. Epub 2022 Nov 10.
Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.
第一组先天淋巴细胞 (ILC) 包括两个主要产生 IFN-γ 的群体，即自然杀伤 (NK) 细胞和 ILC1。最近的研究揭示了浸润不同肿瘤的第一组 ILC 亚群的复杂和多样化组成。在这篇综述中，我们将概述小鼠和人类第一组 ILC 亚群之间的共性和差异，讨论组织和肿瘤微环境如何塑造它们的表型和功能，并描述它们在对不同癌症的反应中的对比作用。
