Wu Shuang, Mei Zhimin, Gao Jin, Chai Songshan
The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, China.
General Hospital of the Yangtze River Shipping, Wuhan Brain Hospital, Wuhan, China.
Front Nutr. 2025 Jun 5;12:1493603. doi: 10.3389/fnut.2025.1493603. eCollection 2025.
Depression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium and depression and stroke. However, the relationship between dietary selenium and depression has not been adequately studied. Therefore, the purpose of this study was to assess the association between dietary selenium and depression among individuals with or without stroke.
A cross-sectional study was performed using the 2011-2018 National Health and Nutrition Examination Survey dataset ( = 15,018). Logistic regression, interaction effect analysis, and restricted cubic spline analysis were used for statistical analyses.
The association between dietary selenium intake and prevalence depression differed between the non-stroke and stroke groups. Furthermore, when dietary selenium was converted into a categorical variable, there was evidence of an interaction between stroke status and selenium intake on decreasing the prevalence of depression ( = 0.007). What's more, the dose-response association between dietary selenium intake and depression indicated various patterns between participants with and without stroke.
A cross-sectional study cannot be used to infer causal relationships.
A non-linear relationship was observed in individuals without stroke, characterized by an apparent threshold of approximately 128.4 mcg/d. In contrast, no association was observed between dietary selenium intake and depression in participants with stroke. Further research is necessary to validate the present findings.
抑郁症和中风是高发性的危及生命的疾病，研究表明饮食中的硒与抑郁症和中风之间存在相互作用。然而，饮食中的硒与抑郁症之间的关系尚未得到充分研究。因此，本研究的目的是评估有或无中风个体中饮食中的硒与抑郁症之间的关联。
使用2011 - 2018年国家健康和营养检查调查数据集（n = 15,018）进行横断面研究。采用逻辑回归、交互效应分析和受限立方样条分析进行统计分析。
非中风组和中风组中饮食硒摄入量与抑郁症患病率之间的关联有所不同。此外，当将饮食中的硒转换为分类变量时，有证据表明中风状态与硒摄入量之间在降低抑郁症患病率方面存在交互作用（P = 0.007）。而且，饮食硒摄入量与抑郁症之间的剂量反应关联在有和无中风的参与者中呈现出不同模式。
横断面研究不能用于推断因果关系。
在无中风个体中观察到非线性关系，其特征是明显的阈值约为128.4微克/天。相比之下，中风参与者的饮食硒摄入量与抑郁症之间未观察到关联。需要进一步研究来验证本研究结果。
