Department of Oncology, Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2022 Apr-Jun;63(2):439-447. doi: 10.47162/RJME.63.2.15.
Tissue healing is a complex, dynamic process, characterized by the replacement of devitalized and absent cell and tissue structures. This can be obtained by different methods, these being found in the "reconstructive scale", which although it is very rich does not offer a universally valid solution for closing skin wounds. In plastic surgery, platelet-rich plasma (PRP) has proven effective in the treatment of skin graft donor areas, burn wounds, skin grafts, tendons, or varicose ulcers. Also, hyaluronic acid (HA) has found its utility in different areas of medicine, other than the esthetics field, with satisfactory results after its use in various lesions. The aim of our study was to find a method of healing wounds with skin defect that shortens the time of complete epithelialization compared to native healing, which is accessible to any patient both by its simplicity and by the lowest possible costs. So, we decided to test a preparation consisting of PRP and granular HA in this type of wounds on a group of 30 Wistar rats. Corroborating the macroscopic data with the microscopic ones, an important similarity can be observed between the healing of the adjuvant-treated lesion at 14 days postoperatively and the healing of the lesion left to natural healing at 21 days, thus shortening the healing period by seven days.
组织愈合是一个复杂的动态过程，其特征是失活和缺失的细胞和组织结构的替代。可以通过不同的方法获得，这些方法存在于“重建尺度”中，尽管它非常丰富，但对于闭合皮肤伤口并没有提供普遍有效的解决方案。在整形手术中，富含血小板的血浆 (PRP) 已被证明可有效治疗皮肤移植物供区、烧伤创面、皮肤移植物、肌腱或静脉曲张性溃疡。此外，透明质酸 (HA) 在医学的不同领域，除了美容领域外，都有其用途，在各种病变中的应用都取得了令人满意的效果。我们的研究目的是找到一种治疗皮肤缺损伤口的方法，与自然愈合相比，这种方法可以缩短完全上皮化的时间，而且任何患者都可以通过其简单性和尽可能低的成本获得这种方法。因此，我们决定在一组 30 只 Wistar 大鼠的这种类型的伤口上测试一种由 PRP 和颗粒状 HA 组成的制剂。将宏观数据与微观数据进行对比，可以观察到在术后 14 天接受辅助治疗的病变的愈合与在术后 21 天自然愈合的病变的愈合之间存在重要的相似性，从而将愈合期缩短了 7 天。
