Fares Mazigh, Brennan Benjamin
Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.
Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK.
Curr Opin Virol. 2022 Dec;57:101278. doi: 10.1016/j.coviro.2022.101278. Epub 2022 Nov 11.
The Bunyavirales order is the largest grouping of RNA viruses, comprising emerging and re-emerging human, plant and animal pathogens. Bunyaviruses have a global distribution and many members of the order are transmitted by arthropods. They have evolved a plethora of mechanisms to manipulate the regulatory processes of the infected cell to facilitate their own replicative cycle, in hosts of disparate phylogenies. Interest in virus-vector interactions is growing rapidly. However, current understanding of tick-borne bunyavirus cellular interaction is heavily biased to studies conducted in mammalian systems. In this short review, we summarise current understandings of how tick-borne bunyaviruses utilise major cellular pathways (innate immunity, apoptosis and RNAi responses) in mammalian or tick cells to facilitate virus replication.
布尼亚病毒目是RNA病毒中最大的一个类群，包含新出现的和再次出现的人类、植物及动物病原体。布尼亚病毒分布于全球，该目中许多成员由节肢动物传播。在不同系统发育的宿主中，它们进化出了大量机制来操纵受感染细胞的调控过程，以促进自身的复制周期。人们对病毒与载体相互作用的兴趣正在迅速增长。然而，目前对蜱传布尼亚病毒细胞相互作用的理解严重偏向于在哺乳动物系统中进行的研究。在这篇简短的综述中，我们总结了目前对蜱传布尼亚病毒如何利用哺乳动物或蜱细胞中的主要细胞途径（固有免疫、细胞凋亡和RNAi反应）来促进病毒复制的理解。
