Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136, United States of America.
Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33136, United States of America; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33136, United States of America.
Neurobiol Dis. 2022 Dec;175:105926. doi: 10.1016/j.nbd.2022.105926. Epub 2022 Nov 12.
The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the passage of nutrients and molecules from the blood to the brain. This is critical for maintaining the proper functioning of the brain, and any disruption in the BBB has detrimental consequences often leading to diseases. It is not clear whether disruption of the BBB occurs first in depression or is the consequence of the disease, however disruption of the BBB has been observed in depressed patients and evidence points to the role of important culprits in depression, stress and inflammation in disrupting the integrity of the BBB. The mechanisms whereby stress, and inflammation affect the BBB remain to be fully understood. Yet, the role of cytokines in regulating tight junction protein expression seems crucial. Altogether, the findings in depression suggest that acting at the BBB level might provide therapeutic benefit in depression.
血脑屏障（BBB）是保护大脑的重要结构，它能严格地筛选血液中的营养物质和分子进入大脑。这对于维持大脑的正常功能至关重要，而 BBB 的任何破坏都会产生有害的后果，通常会导致疾病。目前尚不清楚 BBB 的破坏是先发生在抑郁症中，还是疾病的结果，但已经在抑郁患者中观察到 BBB 的破坏，有证据表明，在抑郁症中，重要的罪魁祸首是压力和炎症破坏了 BBB 的完整性。压力和炎症影响 BBB 的机制仍有待充分理解。然而，细胞因子在调节紧密连接蛋白表达中的作用似乎至关重要。总之，抑郁症中的发现表明，在 BBB 水平上进行干预可能会对抑郁症产生治疗益处。
