Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12 - 56127 Pisa, Italy; NEST-Scuola Normale Superiore, Piazza San Silvestro, 12 - 56127 Pisa, Italy.
Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, Piazza San Silvestro, 12 - 56127 Pisa, Italy; Department of Pharmacy, University of Genoa, Viale Cembrano, 4 - 16148 Genoa, Italy.
Drug Discov Today. 2023 Feb;28(2):103438. doi: 10.1016/j.drudis.2022.103438. Epub 2022 Nov 12.
Angiogenesis and metastasis are two interdependent cancer hallmarks, the latter of which is the key cause of treatment failure. Thus, establishing effective antiangiogenesis/antimetastasis agents is the final frontier in cancer research. Gold nanoparticles (GNPs) may provide disruptive advancements in this regard due to their intrinsic physical and physiological features. Here, we comprehensively discuss recent potential therapeutical strategies to treat angiogenesis and metastasis and present a critical review on the state-of-the-art in vitro and in vivo evaluations of the antiangiogenic/antimetastatic activity of GNPs. Finally, we provide perspectives on the contribution of GNPs to the advancement of cancer management.
血管生成和转移是两个相互依存的癌症标志，后者是治疗失败的关键原因。因此，建立有效的抗血管生成/抗转移药物是癌症研究的最终前沿。由于其固有物理和生理特性，金纳米颗粒（GNPs）可能会在这方面提供颠覆性进展。在这里，我们全面讨论了最近治疗血管生成和转移的潜在治疗策略，并对 GNPs 的抗血管生成/抗转移活性的最新体外和体内评估进行了批判性评价。最后，我们对 GNPs 在癌症管理进展中的贡献提出了展望。
