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Reply to: The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein.

作者信息

Shaban Mohammed Samer, Müller Christin, Mayr-Buro Christin, Weiser Hendrik, Schmitz M Lienhard, Ziebuhr John, Kracht Michael

机构信息

Rudolf Buchheim Institute of Pharmacology, Justus Liebig University, Giessen, Germany.

Institute of Medical Virology, Justus Liebig University, Giessen, Germany.

出版信息

Nat Commun. 2022 Nov 14;13(1):6550. doi: 10.1038/s41467-022-34066-2.

DOI:10.1038/s41467-022-34066-2
PMID:36376283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9663517/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/9663517/7fc7fcfe4eee/41467_2022_34066_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/9663517/7fc7fcfe4eee/41467_2022_34066_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fff0/9663517/7fc7fcfe4eee/41467_2022_34066_Fig1_HTML.jpg

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本文引用的文献

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Thapsigargin: key to new host-directed coronavirus antivirals?他普司他汀：新型靶向宿主冠状病毒抗病毒药物的关键？
Trends Pharmacol Sci. 2022 Jul;43(7):557-568. doi: 10.1016/j.tips.2022.04.004. Epub 2022 Apr 18.
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Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.紧急出现的 SARS-CoV-2 变体：复制动力学的比较和对他普司他汀的高敏感性。
Virulence. 2021 Dec;12(1):2946-2956. doi: 10.1080/21505594.2021.2006960.
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Pharmacological targeting of endoplasmic reticulum stress in disease.内质网应激在疾病中的药理学靶向治疗。
呼吸道上皮细胞中新型冠状病毒与宿主相互作用调节因子的鉴定与靶向研究
bioRxiv. 2024 Dec 9:2024.10.11.617898. doi: 10.1101/2024.10.11.617898.
4
Thapsigargin and Tunicamycin Block SARS-CoV-2 Entry into Host Cells via Differential Modulation of Unfolded Protein Response (UPR), AKT Signaling, and Apoptosis.他普西加林和衣霉素通过差异化调节未折叠蛋白反应（UPR）、AKT 信号和细胞凋亡来阻断 SARS-CoV-2 进入宿主细胞。
Cells. 2024 Apr 30;13(9):769. doi: 10.3390/cells13090769.
Nat Rev Drug Discov. 2022 Feb;21(2):115-140. doi: 10.1038/s41573-021-00320-3. Epub 2021 Oct 26.
4
Multi-level inhibition of coronavirus replication by chemical ER stress.化学内质网应激对冠状病毒复制的多层次抑制作用。
Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1.
5
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies.在 COVID-19 尸检中，肺泡细胞表现出内质网应激生物标志物 GRP78 的高度上调，GRP78 是 SARS-CoV-2 的共受体。
Cell Stress Chaperones. 2021 Sep;26(5):859-868. doi: 10.1007/s12192-021-01230-4. Epub 2021 Aug 12.
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Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury.未折叠蛋白反应抑制减轻中东呼吸综合征冠状病毒诱导的急性肺损伤。
mBio. 2021 Aug 31;12(4):e0157221. doi: 10.1128/mBio.01572-21. Epub 2021 Aug 10.
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Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection.未折叠蛋白反应的调控：一种抗冠状病毒感染的药理学策略。
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