Elfiky Abdo A, Ibrahim Ibrahim M, Amin Fatma G, Ismail Alaa M, Elshemey Wael M
Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Physics Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Adv Exp Med Biol. 2021;1318:169-178. doi: 10.1007/978-3-030-63761-3_10.
The present century will undoubtedly be marked with the COVID-19 global health crisis. It is not time yet to talk about the total number of deaths and hospitalizations, as they are enormously growing daily. Understanding the nature of COVID-19-induced pneumonia is vital in order to deal with the associated health complications. Cell stress is an established mechanism known to be associated with infection and cancer. Different proteins crucial for cellular response to stress are reported to be a possible target to stop the infection and to reduce the chemo-resistance in cancer. Heat shock protein (HSP) families of chaperones play an essential role in cells both in normal state and under stress. The upregulation of HSP5A, also termed GRP78 or Bip, is reported in different viral infections. This chapter introduces the current knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has caused the COVID-19 pandemic, and cell stress aimed at defining possible strategies to combat the COVID-19 pandemic.
本世纪无疑将因新冠疫情这一全球健康危机而被铭记。现在还不是谈论死亡和住院总数的时候，因为它们每天都在大幅增加。了解新冠病毒引发的肺炎的本质对于应对相关健康并发症至关重要。细胞应激是一种已知与感染和癌症相关的既定机制。据报道，对细胞应激反应至关重要的不同蛋白质可能是阻止感染和降低癌症化疗耐药性的靶点。热休克蛋白（HSP）伴侣家族在细胞的正常状态和应激状态下都起着至关重要的作用。据报道，在不同的病毒感染中，HSP5A（也称为GRP78或Bip）会上调。本章介绍了关于导致新冠疫情的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的现有知识以及细胞应激，旨在确定对抗新冠疫情的可能策略。
