Linping Campus of the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Clin Transl Oncol. 2023 Mar;25(3):620-632. doi: 10.1007/s12094-022-02995-5. Epub 2022 Nov 14.
Different types of cells that are involved in tumor immunity play a significant part in antitumor therapy. The intestinal microbiota consist of the trillions of diverse microorganisms that inhabit the gastrointestinal tract. Recently, much emphasis has been paid to the link between these symbionts and colorectal cancer (CRC). This association might be anything from oncogenesis and cancer development to resistance or susceptibility to chemotherapeutic medicines. Cancer patients have a significantly different microbial composition in their guts compared to healthy persons. The microbiome may play a role in the development and development of cancer through the modulation of tumor immunosurveillance, as shown by these studies; however, the specific processes underlying this role are still poorly understood. This review focuses on the relationship between the intestinal bacterial microbiota and immune cells to determine how the commensal microbiome influences the initiation and development of CRC.
不同类型的参与肿瘤免疫的细胞在抗肿瘤治疗中起着重要作用。肠道微生物群由居住在胃肠道中的数万亿种不同微生物组成。最近，人们非常关注这些共生体与结直肠癌（CRC）之间的联系。这种关联可能涉及从致癌作用和癌症发展到对化疗药物的耐药性或易感性。与健康人相比，癌症患者的肠道微生物组成有明显的不同。这些研究表明，微生物组可能通过调节肿瘤免疫监视在癌症的发生和发展中发挥作用；然而，这种作用的具体过程仍知之甚少。这篇综述重点关注肠道细菌微生物群和免疫细胞之间的关系，以确定共生微生物群如何影响 CRC 的发生和发展。
