Department of Infectious Diseases, Sir Run Run Shaw Hospitalgrid.415999.9, Zhejiang Universitygrid.13402.34 School of Medicine, Hangzhou, China.
Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China.
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0082822. doi: 10.1128/aac.00828-22. Epub 2022 Nov 15.
Cefiderocol is a novel siderophore cephalosporin that displays activity against Gram-negative bacteria. To establish cefiderocol susceptibility levels of Acinetobacter baumannii strains from China, we performed susceptibility testing and genomic analyses on 131 clinical isolates. Cefiderocol shows high activity against the strains. The production of PER-1 is the key mechanism of cefiderocol resistance. studies predicted that avibactam and durlobactam could inhibit cefiderocol hydrolysis by PER-1, which was confirmed by determining cefiderocol MICs in combination with inhibitors.
头孢他啶罗是一种新型的铁载体头孢菌素,对革兰氏阴性菌具有活性。为了确定中国鲍曼不动杆菌菌株对头孢他啶罗的敏感性水平,我们对 131 株临床分离株进行了药敏试验和基因组分析。头孢他啶罗对这些菌株表现出很高的活性。PER-1 的产生是头孢他啶罗耐药的关键机制。研究预测,阿维巴坦和杜拉西林可以抑制 PER-1 对头孢他啶罗的水解,这一结论通过测定与抑制剂联合使用的头孢他啶罗 MIC 得到了证实。