• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Insights into the activity of cefiderocol against PER-2 producing Enterobacterales.对头孢地尔对产PER-2肠杆菌科细菌活性的见解。
Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0172023. doi: 10.1128/aac.01720-23. Epub 2024 May 1.
2
Tackling the unyielding: testing two novel approaches against NDM-producing Enterobacterales and isolates collected in India.攻克顽固病菌：针对在印度收集的产NDM肠杆菌科细菌及分离株测试两种新方法
Microbiol Spectr. 2025 Jan 7;13(1):e0049724. doi: 10.1128/spectrum.00497-24. Epub 2024 Nov 19.
3
Assessment of the activity and mechanisms of resistance to cefiderocol and combinations of β-lactams and the novel β-lactamase inhibitors avibactam, taniborbactam, zidebactam, nacubactam, xeruborbactam, and ANT3310 in emerging double-carbapenemase-producing Enterobacterales.评估新型头孢地尔肟的活性和耐药机制，以及β-内酰胺类药物与新型β-内酰胺酶抑制剂阿维巴坦、替加环素、唑巴坦、奈拉滨、西罗莫司他和 ANT3310 联合使用对新兴产双重碳青霉烯酶肠杆菌科的作用机制。
Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0092424. doi: 10.1128/aac.00924-24. Epub 2024 Oct 9.
4
In vitro activity of cefiderocol, a siderophore cephalosporin, against a recent collection of clinically relevant carbapenem-non-susceptible Gram-negative bacilli, including serine carbapenemase- and metallo-β-lactamase-producing isolates (SIDERO-WT-2014 Study).头孢地尔罗的体外活性，一种铁载体头孢菌素，针对最近收集的临床相关碳青霉烯类药物不敏感的革兰氏阴性杆菌，包括丝氨酸碳青霉烯酶和金属β-内酰胺酶产生的分离株（SIDERO-WT-2014 研究）。
Int J Antimicrob Agents. 2019 Feb;53(2):177-184. doi: 10.1016/j.ijantimicag.2018.10.007. Epub 2018 Oct 26.
5
In vitro antimicrobial activity of six novel β-lactam and β-lactamase inhibitor combinations and cefiderocol against NDM-producing Enterobacterales in China.六种新型β-内酰胺与β-内酰胺酶抑制剂组合及头孢地尔在中国针对产NDM肠杆菌科细菌的体外抗菌活性
Int J Antimicrob Agents. 2025 Feb;65(2):107407. doi: 10.1016/j.ijantimicag.2024.107407. Epub 2024 Dec 11.
6
activity assessment of cefiderocol against Enterobacterales, and spp., including β-lactam nonsusceptible molecularly characterized isolates, collected from 2020 to 2021 in the United States and European hospitals.头孢地尔在美欧医院 2020 年至 2021 年收集的包括对β-内酰胺类药物不敏感的分子特征分离株的肠杆菌科和 属的活性评估。
Microbiol Spectr. 2024 Nov 5;12(11):e0147424. doi: 10.1128/spectrum.01474-24. Epub 2024 Oct 10.
7
Activity of Cefiderocol, a Siderophore Cephalosporin, against Multidrug-Resistant Gram-Negative Bacteria.头孢他啶美罗培南复方制剂（cefiderocol）对多重耐药革兰氏阴性菌的活性。
Antimicrob Agents Chemother. 2020 Nov 17;64(12). doi: 10.1128/AAC.01582-20.
8
Contribution of PER-Type and NDM-Type β-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii.鲍曼不动杆菌中 PER 型和 NDM 型β-内酰胺酶对头孢地尔罗耐药性的贡献。
Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0087721. doi: 10.1128/AAC.00877-21. Epub 2021 Jul 12.
9
Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.头孢地尔：一种具有抗碳青霉烯类和多药耐药革兰氏阴性杆菌活性的铁载体头孢菌素。
Drugs. 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2.
10
Antimicrobial Activity of Cefiderocol against the Carbapenemase-Producing Enterobacter cloacae Complex and Characterization of Reduced Susceptibility Associated with Metallo-β-Lactamase VIM-1.头孢地尔罗对产碳青霉烯酶阴沟肠杆菌复合体的抗菌活性及与金属β-内酰胺酶 VIM-1 相关的低敏感性的特征。
Antimicrob Agents Chemother. 2023 May 17;67(5):e0150522. doi: 10.1128/aac.01505-22. Epub 2023 Apr 13.

本文引用的文献

1
Genomic characterization of an NDM-9-producing clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9.一株产NDM-9临床分离株的基因组特征及Glu152Lys替换在增强NDM-9对头孢地尔水解作用中的作用
Front Microbiol. 2023 Aug 28;14:1253160. doi: 10.3389/fmicb.2023.1253160. eCollection 2023.
2
Human serum albumin-induced modification of Ton-B-dependent receptor expression in cefiderocol-exposed carbapenem-resistant Acinetobacter baumannii.人血清白蛋白诱导头孢地尔暴露的耐碳青霉烯鲍曼不动杆菌中Ton-B依赖性受体表达的改变
Int J Antimicrob Agents. 2023 Nov;62(5):106950. doi: 10.1016/j.ijantimicag.2023.106950. Epub 2023 Aug 18.
3
Diversity of genetic platforms harboring the bla gene in Enterobacterales and insights into the role of ISPa12 in its mobilization and dissemination.肠杆菌科中携带 bla 基因的基因平台多样性及其在移动和传播中的作用的研究。
Int J Antimicrob Agents. 2023 Jul;62(1):106850. doi: 10.1016/j.ijantimicag.2023.106850. Epub 2023 May 11.
4
Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii.鲍曼不动杆菌中 PER-1 介导的头孢地尔耐药的结构基础以及头孢地尔与阿维巴坦或多利布坦联用对 PER-1 的协同抑制作用。
Antimicrob Agents Chemother. 2022 Dec 20;66(12):e0082822. doi: 10.1128/aac.00828-22. Epub 2022 Nov 15.
5
Contribution of PER-Type and NDM-Type β-Lactamases to Cefiderocol Resistance in Acinetobacter baumannii.鲍曼不动杆菌中 PER 型和 NDM 型β-内酰胺酶对头孢地尔罗耐药性的贡献。
Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0087721. doi: 10.1128/AAC.00877-21. Epub 2021 Jul 12.
6
ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and with Defined Extended-Spectrum β-Lactamases and Carbapenemases.ARGONAUT-I 研究：头孢他啶罗（S-649266），一种新型的具有铁载体结构的头孢菌素，对革兰氏阴性菌的活性，包括碳青霉烯类耐药非发酵菌和具有明确的扩展谱β-内酰胺酶和碳青霉烯酶。
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01801-18. Print 2019 Jan.
7
Stability and low induction propensity of cefiderocol against chromosomal AmpC β-lactamases of Pseudomonas aeruginosa and Enterobacter cloacae.头孢地尔在铜绿假单胞菌和阴沟肠杆菌染色体 AmpCβ-内酰胺酶中的稳定性和低诱导倾向。
J Antimicrob Chemother. 2018 Nov 1;73(11):3049-3052. doi: 10.1093/jac/dky317.
8
Defining Substrate Specificity in the CTX-M Family: the Role of Asp240 in Ceftazidime Hydrolysis.CTX-M 家族中底物特异性的定义：天冬氨酸 240 在头孢他啶水解中的作用。
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.00116-18. Print 2018 Jun.
9
Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.碳青霉烯酶 2（KPC-2），在 Ambler 位置 Asp179 的取代以及对头孢他啶-阿维巴坦的耐药性：β-内酰胺酶蛋白质工程产生独特的抗生素耐药表型。
mBio. 2017 Oct 31;8(5):e00528-17. doi: 10.1128/mBio.00528-17.
10
Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria.头孢地尔的抗菌特性，一种新型的铁载体头孢菌素，针对革兰氏阴性菌。
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01454-17. Print 2018 Jan.

对头孢地尔对产PER-2肠杆菌科细菌活性的见解。

Insights into the activity of cefiderocol against PER-2 producing Enterobacterales.

作者信息

Ruggiero Melina, Briceño Muñoz Ivan, Gutkind Gabriel, Hujer Andrea M, Bonomo Robert A, Power Pablo

机构信息

Universidad de Buenos Aires, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Buenos Aires, Argentina.

Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

出版信息

Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0172023. doi: 10.1128/aac.01720-23. Epub 2024 May 1.

DOI:10.1128/aac.01720-23
PMID:38690895
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11620487/
Abstract

The PER-2 β-lactamase is a unique class A enzyme conferring broad spectrum cephalosporin resistance. In this study, we explored the stability of cefiderocol (FDC) against PER-2 β-lactamase to gain insights into structure activity relationships (SAR) of this synthetic siderophore-conjugated antibiotic. Herein, we show that the MICs of FDC for PER-2 producing isolates and transformants ranged between 0.125 and 64 µg/mL; diazabicyclooctanes (DBOs) reduced the MIC values. In PER-2 mutants, MIC values decreased up to 10-12 dilutions in agreement with previous observations especially in the case of Arg220 substitutions. Catalytic efficiency for PER-2 was 0.072 µM s, comparable with PER-1 (0.046 µM s) and NDM-1 (0.067 µM s). models revealed that FDC within the active site of PER-2 demonstrates unique interactions as a result of the inverted Ω loop fold and extension of the β3-β4 connecting loop.

摘要

PER-2β-内酰胺酶是一种独特的A类酶，可赋予对广谱头孢菌素的抗性。在本研究中，我们探究了头孢地尔（FDC）对PER-2β-内酰胺酶的稳定性，以深入了解这种合成铁载体缀合抗生素的构效关系（SAR）。在此，我们表明FDC对产PER-2的分离株和转化体的最低抑菌浓度（MIC）范围在0.125至64μg/mL之间；二氮杂双环辛烷（DBO）降低了MIC值。在PER-2突变体中，MIC值降低了多达10至12倍稀释度，这与先前的观察结果一致，尤其是在精氨酸220替代的情况下。PER-2的催化效率为0.072μM/s，与PER-1（0.046μM/s）和NDM-1（0.067μM/s）相当。模型显示，由于反向Ω环折叠和β3-β4连接环的延伸，PER-2活性位点内的FDC表现出独特的相互作用。