南美洲未接种新冠疫苗的最年长新冠病毒幸存者。
The oldest unvaccinated Covid-19 survivors in South America.
作者信息
de Castro Mateus V, Silva Monize V R, Naslavsky Michel S, Scliar Marilia O, Nunes Kelly, Passos-Bueno Maria Rita, Castelli Erick C, Magawa Jhosiene Y, Adami Flávia L, Moretti Ana I S, de Oliveira Vivian L, Boscardin Silvia B, Cunha-Neto Edecio, Kalil Jorge, Jouanguy Emmanuelle, Bastard Paul, Casanova Jean-Laurent, Quiñones-Vega Mauricio, Sosa-Acosta Patricia, Guedes Jéssica de S, de Almeida Natália P, Nogueira Fábio C S, Domont Gilberto B, Santos Keity S, Zatz Mayana
机构信息
Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.
Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.
出版信息
Immun Ageing. 2022 Nov 16;19(1):57. doi: 10.1186/s12979-022-00310-y.
BACKGROUND
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.
RESULTS
Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.
CONCLUSION
These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
背景
尽管老年人感染新冠病毒后出现重症或危重症的风险很高，但仍有许多未接种疫苗的百岁老人发生了无症状感染，或从轻度或中度新冠感染中康复。我们研究了三位年龄超过110岁的巴西超级百岁老人，他们在2020年接种疫苗之前感染了新冠病毒但存活了下来。
结果
尽管他们年事已高，但体液免疫反应分析表明，这些个体针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）表现出强大的免疫球蛋白G（IgG）和中和抗体（NAbs）水平。还观察到与先天免疫反应和宿主防御相关的血浆蛋白和代谢物有所富集。没有人出现针对I型干扰素（IFN）的自身抗体（自身抗体）。此外，这些超级百岁老人在已知的先天性免疫缺陷相关基因中没有携带罕见变异，包括特定的I型干扰素先天性缺陷。
结论
这些观察结果表明，他们对新冠病毒的抵抗力可能是其遗传背景以及先天和适应性免疫共同作用的结果。
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