• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

南美洲未接种新冠疫苗的最年长新冠病毒幸存者。

The oldest unvaccinated Covid-19 survivors in South America.

作者信息

de Castro Mateus V, Silva Monize V R, Naslavsky Michel S, Scliar Marilia O, Nunes Kelly, Passos-Bueno Maria Rita, Castelli Erick C, Magawa Jhosiene Y, Adami Flávia L, Moretti Ana I S, de Oliveira Vivian L, Boscardin Silvia B, Cunha-Neto Edecio, Kalil Jorge, Jouanguy Emmanuelle, Bastard Paul, Casanova Jean-Laurent, Quiñones-Vega Mauricio, Sosa-Acosta Patricia, Guedes Jéssica de S, de Almeida Natália P, Nogueira Fábio C S, Domont Gilberto B, Santos Keity S, Zatz Mayana

机构信息

Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, São Paulo, Brazil.

Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, São Paulo, Brazil.

出版信息

Immun Ageing. 2022 Nov 16;19(1):57. doi: 10.1186/s12979-022-00310-y.

DOI:10.1186/s12979-022-00310-y
PMID:36384671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9666972/
Abstract

BACKGROUND

Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.

RESULTS

Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.

CONCLUSION

These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.

摘要

背景

尽管老年人感染新冠病毒后出现重症或危重症的风险很高，但仍有许多未接种疫苗的百岁老人发生了无症状感染，或从轻度或中度新冠感染中康复。我们研究了三位年龄超过110岁的巴西超级百岁老人，他们在2020年接种疫苗之前感染了新冠病毒但存活了下来。

结果

尽管他们年事已高，但体液免疫反应分析表明，这些个体针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）表现出强大的免疫球蛋白G（IgG）和中和抗体（NAbs）水平。还观察到与先天免疫反应和宿主防御相关的血浆蛋白和代谢物有所富集。没有人出现针对I型干扰素（IFN）的自身抗体（自身抗体）。此外，这些超级百岁老人在已知的先天性免疫缺陷相关基因中没有携带罕见变异，包括特定的I型干扰素先天性缺陷。

结论

这些观察结果表明，他们对新冠病毒的抵抗力可能是其遗传背景以及先天和适应性免疫共同作用的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a54/9667627/cd655a6f3b17/12979_2022_310_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a54/9667627/d7dae4758752/12979_2022_310_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a54/9667627/cd655a6f3b17/12979_2022_310_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a54/9667627/d7dae4758752/12979_2022_310_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a54/9667627/cd655a6f3b17/12979_2022_310_Fig2_HTML.jpg

相似文献

1
The oldest unvaccinated Covid-19 survivors in South America.南美洲未接种新冠疫苗的最年长新冠病毒幸存者。
Immun Ageing. 2022 Nov 16;19(1):57. doi: 10.1186/s12979-022-00310-y.
2
Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19.百岁老人、半超百岁老人、新冠病毒与西班牙流感：一项血清学评估，以深入了解年长百岁老人对新冠病毒的抵抗力。
Immun Ageing. 2024 Jun 27;21(1):44. doi: 10.1186/s12979-024-00450-3.
3
Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia.在危及生命的 COVID-19 肺炎期间，至少有 10%的患者的支气管肺泡灌洗液中存在中和 I 型 IFNs 的自身抗体。
J Clin Immunol. 2023 Aug;43(6):1093-1103. doi: 10.1007/s10875-023-01512-9. Epub 2023 May 20.
4
Humoral Immunity of Unvaccinated COVID-19 Recovered vs. Naïve BNT162b2 Vaccinated Individuals: A Prospective Longitudinal Study.未接种疫苗的新冠康复者与单纯接种BNT162b2疫苗者的体液免疫：一项前瞻性纵向研究。
Microorganisms. 2023 Jun 22;11(7):1628. doi: 10.3390/microorganisms11071628.
5
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs.疫苗突破性低氧血症 COVID-19 肺炎患者的自身抗体中和 I 型 IFNs。
Sci Immunol. 2023 Dec 22;8(90):eabp8966. doi: 10.1126/sciimmunol.abp8966.
6
SARS-CoV-2 T Cell Response in Severe and Fatal COVID-19 in Primary Antibody Deficiency Patients Without Specific Humoral Immunity.严重和致命的新型冠状病毒肺炎（COVID-19）中，原发性抗体缺陷患者无特异性体液免疫时的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）T细胞反应
Front Immunol. 2022 Mar 10;13:840126. doi: 10.3389/fimmu.2022.840126. eCollection 2022.
7
Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization.接种疫苗后住院的 SARS-CoV-2 突破性感染的临床和免疫学特征。
J Clin Immunol. 2022 Oct;42(7):1379-1391. doi: 10.1007/s10875-022-01325-2. Epub 2022 Jul 9.
8
[Investigation of SARS-CoV-2-Specific Humoral and Cellular Immunity Values in Health Care Workers with COVID-19 Disease and Administered with COVID-19 Vaccine].[对感染新冠病毒疾病并接种新冠疫苗的医护人员的新冠病毒特异性体液免疫和细胞免疫值的调查]
Mikrobiyol Bul. 2022 Jul;56(3):480-492. doi: 10.5578/mb.20229708.
9
BNT162b2 COVID-19 vaccination elicited protective robust immune responses in pediatric patients with inborn errors of metabolism.BNT162b2 COVID-19 疫苗在患有先天性代谢缺陷的儿科患者中引发了保护性的强烈免疫反应。
Front Immunol. 2023 Jan 5;13:1082192. doi: 10.3389/fimmu.2022.1082192. eCollection 2022.
10
Pediatric population (aged 3-11 years) received primary inactivated SARS-CoV-2 vaccination prior to infection exhibiting robust humoral immune response following infected with Omicron variant: a study conducted in Beijing.在北京进行的一项研究表明，3至11岁的儿童群体在感染奥密克戎变异株之前接种了新冠病毒灭活疫苗，感染后表现出强大的体液免疫反应。
Front Immunol. 2023 Sep 27;14:1269665. doi: 10.3389/fimmu.2023.1269665. eCollection 2023.

引用本文的文献

1
Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19.百岁老人、半超百岁老人、新冠病毒与西班牙流感：一项血清学评估，以深入了解年长百岁老人对新冠病毒的抵抗力。
Immun Ageing. 2024 Jun 27;21(1):44. doi: 10.1186/s12979-024-00450-3.
2
Human genetic determinants of COVID-19 in Brazil: challenges and future plans.巴西新冠病毒病的人类遗传决定因素：挑战与未来计划
Genet Mol Biol. 2024 Jan 15;46(3 Suppl 1):e20230128. doi: 10.1590/1678-4685-GMB-2023-0128. eCollection 2024.
3
The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity.

本文引用的文献

1
The "original antigenic sin" and its relevance for SARS-CoV-2 (COVID-19) vaccination.“原始抗原罪”及其与严重急性呼吸综合征冠状病毒2（SARS-CoV-2，即新型冠状病毒肺炎）疫苗接种的相关性。
Clin Immunol Commun. 2021 Dec;1:13-16. doi: 10.1016/j.clicom.2021.10.001. Epub 2021 Oct 8.
2
Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults.免疫系统衰老：延长老年人健康寿命面临的研究挑战。
Front Aging. 2020 Oct 15;1:602108. doi: 10.3389/fragi.2020.602108. eCollection 2020.
3
Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients.
对2020年12月28日至2021年9月23日期间最年长的意大利男性A.T.的表型特征分析，强化了免疫系统在实现超长寿命中可发挥关键作用这一观点。
J Clin Med. 2023 Dec 9;12(24):7591. doi: 10.3390/jcm12247591.
4
Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient.性别和年龄对 COVID-19 致死结局的影响：女性和百岁以上老年人更具韧性。
Int J Mol Sci. 2023 Jan 30;24(3):2638. doi: 10.3390/ijms24032638.
5
Correction: The oldest unvaccinated Covid-19 survivors in South America.更正：南美洲未接种新冠疫苗的最年长幸存者。
Immun Ageing. 2022 Dec 7;19(1):61. doi: 10.1186/s12979-022-00319-3.
入院时血液中糖酵解副产物甲基乙二醛水平升高是 ICU COVID-19 患者死亡的独立生物标志物。
Sci Rep. 2022 Jun 9;12(1):9510. doi: 10.1038/s41598-022-12751-y.
4
Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil.巴西圣保罗 1171 名混合人群的全基因组测序。
Nat Commun. 2022 Mar 4;13(1):1004. doi: 10.1038/s41467-022-28648-3.
5
Neutralizing Antibody Responses to SARS-CoV-2 in Recovered COVID-19 Patients Are Variable and Correlate With Disease Severity and Receptor-Binding Domain Recognition.恢复期 COVID-19 患者对 SARS-CoV-2 的中和抗体反应具有变异性，与疾病严重程度和受体结合域识别相关。
Front Immunol. 2022 Jan 31;13:830710. doi: 10.3389/fimmu.2022.830710. eCollection 2022.
6
Human genetic and immunological determinants of critical COVID-19 pneumonia.人类遗传和免疫因素决定新冠肺炎重症肺炎。
Nature. 2022 Mar;603(7902):587-598. doi: 10.1038/s41586-022-04447-0. Epub 2022 Jan 28.
7
Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response.既往针对人类普通感冒冠状病毒的体液免疫会对 SARS-CoV-2 抗体的保护性应答产生负面影响。
Cell Host Microbe. 2022 Jan 12;30(1):83-96.e4. doi: 10.1016/j.chom.2021.12.005. Epub 2021 Dec 7.
8
Assessment of Polyunsaturated Fatty Acids on COVID-19-Associated Risk Reduction.多不饱和脂肪酸对降低新冠肺炎相关风险的评估
Rev Bras Farmacogn. 2022;32(1):50-64. doi: 10.1007/s43450-021-00213-x. Epub 2021 Dec 2.
9
Immune system cells from COVID-19 patients display compromised mitochondrial-nuclear expression co-regulation and rewiring toward glycolysis.新冠病毒肺炎患者的免疫系统细胞表现出线粒体-细胞核表达共调控受损以及向糖酵解的重编程。
iScience. 2021 Dec 17;24(12):103471. doi: 10.1016/j.isci.2021.103471. Epub 2021 Nov 18.
10
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity.多因素血清学分析揭示了既往人类冠状病毒反应对 SARS-CoV-2 免疫的贡献。
Nat Commun. 2021 Nov 18;12(1):6703. doi: 10.1038/s41467-021-27040-x.