Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P. O. Box 1982, Dammam, 31441, Saudi Arabia.
Department of Internal Medicine, Dammam Medical Complex, Dammam, Saudi Arabia.
Sci Rep. 2022 Jun 9;12(1):9510. doi: 10.1038/s41598-022-12751-y.
Biomarkers to identify ICU COVID-19 patients at high risk for mortality are urgently needed for therapeutic care and management. Here we found plasma levels of the glycolysis byproduct methylglyoxal (MG) were 4.4-fold higher in ICU patients upon admission that later died (n = 33), and 1.7-fold higher in ICU patients that survived (n = 32),compared to uninfected controls (n = 30). The increased MG in patients that died correlated inversely with the levels of the MG-degrading enzyme glyoxalase-1 (r = - 0.50), and its co-factor glutathione (r = - 0.63), and positively with monocytes (r = 0.29). The inflammation markers, SSAO (r = 0.52), TNF-α (r = 0.41), IL-1β (r = 0.25), CRP (r = 0.26) also correlated positively with MG. Logistic regression analysis provides evidence of a significant relationship between the elevated MG upon admission into ICU and death (P < 0.0001), with 42% of the death variability explained. From these data we conclude that elevated plasma MG on admission is a novel independent biomarker that predicts mortality in ICU COVID-19 patients.
我们发现，在入住 ICU 后死亡的 COVID-19 患者（n=33）的血浆中，糖酵解副产物甲基乙二醛（MG）的水平比未感染对照者（n=30）高 4.4 倍，而在存活的 ICU 患者（n=32）中则高 1.7 倍。死亡患者的 MG 增加与 MG 降解酶甘油醛-1（r=-0.50）及其辅因子谷胱甘肽（r=-0.63）的水平呈负相关，与单核细胞（r=0.29）呈正相关。炎症标志物 SSAO（r=0.52）、TNF-α（r=0.41）、IL-1β（r=0.25）和 CRP（r=0.26）也与 MG 呈正相关。逻辑回归分析提供了证据，表明 ICU 入院时升高的 MG 与死亡之间存在显著关系（P<0.0001），可解释 42%的死亡变异性。从这些数据中我们得出结论，入院时血浆 MG 升高是 COVID-19 重症患者死亡的一个新的独立生物标志物。
