Sun Shengkai, Zhao Yuewu, Wang Jine, Pei Renjun
State Key Laboratory of Natural Medicines, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, China.
CAS Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.
J Mater Chem B. 2022 Nov 30;10(46):9535-9564. doi: 10.1039/d2tb01884e.
Metal-organic frameworks (MOFs) have attracted considerable attention as emerging nanomaterials. Based on their tunable size, high porosity, and large specific surface area, MOFs have a wide range of applications in the fields of chemistry, energy, and biomedicine. However, the MOF materials obtained from lanthanides with a unique electronic configuration as inorganic building units have unique properties such as optics, magnetism, and radioactivity. In this study, various synthetic methods for preparing MOF materials using lanthanides as inorganic building units are described. Combined with the characteristics of lanthanides, their application prospects of lanthanide-based MOFs in tumor diagnosis and treatment are emphasized. The authors hope to provide methodological reference for the construction of MOF materials of rare-earth elements, and to provide ideas and inspiration for their practical applications in the field of biomedicine.
金属有机框架材料（MOFs）作为新兴的纳米材料已引起了广泛关注。基于其可调节的尺寸、高孔隙率和大比表面积，MOFs在化学、能源和生物医学领域有着广泛的应用。然而，以具有独特电子构型的镧系元素作为无机构筑单元所获得的MOF材料具有光学、磁性和放射性等独特性质。在本研究中，描述了以镧系元素作为无机构筑单元制备MOF材料的各种合成方法。结合镧系元素的特性，强调了基于镧系元素的MOFs在肿瘤诊断和治疗中的应用前景。作者希望为稀土元素MOF材料的构建提供方法学参考，并为其在生物医学领域的实际应用提供思路和启发。
